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PHOL 483. Translational Physiology I. 3 Units.

Physiology is the dynamic study of life, describing the vital functions of living organisms and their organs, cells, and molecules. For some clinicians, physiology is the function of an individual organ system. For others, it focuses on the cellular principles that are common to the function of all organs and tissues. Medical physiology deals with how the human body functions, which depends on individual organ systems function, which depends on cellular function, which in turn depends on molecular interactions. Translational Physiology I will explore examples of how the latest basic research in physiology and biophysics is being applied to the treatment of human disease. For example, while the students are studying the basic principles of cardiovascular physiology, they will also be investigating how these principles are being applied to treat/cure human cardiovascular disorders such as congestive heart failure, coronary artery disease, etc. Translational Physiology I is a lecture course (1, 2hr lecture/week, and 1, 1hr lecture/week) taught by clinical and basic science faculty. The 2 hour lecture will be given primarily by clinical faculty and is focused on applying physiological principles to clinical cases of pathophysiology. The 1 hour lecture will be given primarily by basic science faculty and will expose students to the process of translating fundamental basic science research to the clinic, that is bench-to-bedside. It is the first of a two-part course that follows the topics being simultaneously covered in the Medical Physiology I course. It is divided into 4 blocks: Block 1 covers the physiology of cells and molecules, signal transduction, basic electrophysiology, and muscle physiology; Block 2 covers the nervous system; Block 3 covers the cardiovascular system, and; Block 4 covers the respiratory system. Grading in the course will be based on performance on multiple choice examinations administered at the end of each block with each examination weighted according to the number of lectures contained in the block.