2013-14 General Bulletin

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212 Clapp Hall
www.case.edu/artsci/chem
Phone: 216.368.3620; Fax: 216.368.3006
Mary D. Barkley, Department Chair

The Department of Chemistry is the largest department representing the chemical sciences at Case Western Reserve University. It consists of 21 faculty members, 16 associated faculty, about 14 postdoctoral associates, approximately 90 graduate students, and over 150 undergraduate students majoring in chemistry. The department offers undergraduate and graduate degree programs leading to the Bachelor of Arts, Bachelor of Science, Master of Science, and Doctor of Philosophy.

The general focus of chemistry is on (1) understanding the basic properties of matter, and (2) employing this knowledge in the design, synthesis, and characterization of materials with novel and useful properties. The various degree programs strive to develop all aspects of the student’s chemical knowledge through a broad range of lecture and laboratory courses.

Chemical research is an integral part of the department’s activities: over $3 million of federal, state, and private research support flows into the department each year. State-of-the-art research facilities are available to both graduate and undergraduate students. Undergraduates are encouraged to participate in research projects with individual faculty members in order to expand their hands-on training, problem-solving skills, and understanding of the scientific method as applied in chemical research. These research projects typically involve interchange and collaboration across all levels of experience and may also involve scientists from other departments and institutions.

Chemistry is often referred to as “the central science” because of its key role in interdisciplinary studies. Correspondingly, a degree in chemistry affords a broad range of employment opportunities. Chemists can direct their talents to specialized problems of applied research, or they can choose to delve into fundamental investigations. A degree in chemistry can cover the spectrum of chemical specialties, from biochemistry to interstellar chemistry. The degree also provides valuable preparation for other professions, such as medicine, dentistry, and law.

The American Chemical Society, with more than 160,000 members, is the major professional society in the United States for practicing chemists. Both undergraduate and graduate students may join the society. 

Facilities

The department’s facilities for experimental and theoretical research are modern and extensive. They include diverse major instruments for use by faculty and students, as well as specialized equipment serving individual research groups. Shared instrumentation includes 400- and 600-MHz NMR spectrometers, ultrafast laser systems in the Center for Chemical Dynamics, and a cyber-enabled X-ray crystallographic facility.

Other departmental instrumentation includes equipment for laser Raman spectroscopy, GC-MS and LC-MS/MS mass spectrometers, calorimeters, stopped-flow kinetics instrumentation, a circular dichroism spectrometer, an analytical ultracentrifuge, and equipment for electrochemical measurements. Access to very high-field NMR instrumentation is available on campus at the Cleveland Center for Membrane Structural Biology (CCMSB), which is equipped with numerous 500- to 900-MHz NMR spectrometers for solution and solid-state measurements. The chemistry department’s computers are part of the campus-wide fiber optic communications network operated by Information Technology Services, and the entire University Circle area offers wireless access. In addition to the full complement of software, Internet, and library database services offered by the university, connections to off-site databases, such as SciFinder and Ohio Supercomputer Center, are available to departmental users.

The department uses some of the foremost equipment available in high-resolution nuclear magnetic resonance spectroscopy and in tunable laser spectroscopy. Work on various aspects of chemistry as studied by these techniques is recognized throughout the world.

Primary Faculty

Mary D. Barkley, PhD
(University of California, San Diego)
M. Roger Clapp University Professor of Arts and Sciences and Chair
Analytical Chemistry, Biochemistry, Biophysical Chemistry, Medicinal Chemistry, Photochemistry, Physical Chemistry, Theoretical Chemistry

Alfred B. Anderson, PhD
(Johns Hopkins University)
Professor
Materials, Physical Chemistry, Catalysis, Theoretical Chemistry

Clemens Burda, PhD
(University of Basel, Switzerland)
Professor
Photochemistry, Materials, Physical Chemistry, Nanochemistry, Bio- and Energy Applications, Biophysical and Biomedical Science and Engineering, Spectroscopy

James D. Burgess, PhD
(Virginia Commonwealth University)
Associate Professor
Analytical Chemistry, Biochemistry, Biophysical Chemistry, Materials, Medicinal Chemistry, Bio-Inorganic Chemistry, Electrochemistry

Carlos E. Crespo-Hernández, PhD
(University of Puerto Rico)
Frank Hovorka Assistant Professor in Chemistry
Analytical Chemistry, Biophysical Chemistry, Energy, Photochemistry, Physical Chemistry, Chemical Dynamics and Kinetics, Computational Chemistry, Environmental Chemistry, Time-Resolved Spectroscopy

Thomas G. Gray, PhD
(Harvard University)
Associate Professor
Organometallic Chemistry, Inorganic Chemistry, Energy, Green Chemistry

Malcolm E. Kenney, PhD
(Cornell University)
Hurlbut Professor of Chemistry
Biochemistry, Inorganic Chemistry, Materials & Energy, Organometallic Chemistry, Bio-Inorganic Chemistry, Computational Chemistry, Drug Delivery, Dyes & Pigments, Medicinal Chemistry, Nanotechnology, Organosilicon Chemistry, Photochemistry, Photodynamic Therapy, Polymers

Irene Lee, PhD
(Pennsylvania State University)
Professor
Biochemistry, Bio-Organic Chemistry, Medicinal Chemistry

Anthony J. Pearson, PhD
(University of Aston, Birmingham, England)
Rudolph and Susan Rense Professor of Chemistry
Organic Chemistry, Organometallic Chemistry, Catalysis, Natural Products, Synthesis

Emily Pentzer, PhD
(Northwestern University)
Assistant Professor
Organic Chemistry, Materials & Energy, Polymers, Nanostructures, Self-Assembly, Composites

John D. Protasiewicz, PhD
(Cornell University)
Professor and Associate Chair
Inorganic Chemistry, Materials & Energy, Organometallic Chemistry, Photochemistry, Catalysis, Computational Chemistry, Crystallography, Electrochemistry, Green Chemistry, Main Group Chemistry, Molecular Electronics, Nanotechnology, OLEDs, Optoelectronics, Physical Organic Chemistry, Polymers, Solar Energy, Solid-State Chemistry, Spectroscopy, Supramolecular Chemistry, Synthesis

Robert G. Salomon, PhD
(University of Wisconsin, Madison)
Charles Frederic Mabery Professor of Research in Chemistry
Biochemistry, Chemical Biology, Medicinal Chemistry, Organic Chemistry, Bio-Organic Chemistry, Cellular Biology, Molecular Biology, Natural Products, Pharmacology, Synthesis

Anna C. Samia, PhD
(Georgia Institute of Technology)
Assistant Professor
Analytical Chemistry, Inorganic Chemistry, Materials & Energy, Bio-Inorganic Chemistry, Functional Nanomaterials, Nanotheranostics

Geneviève Sauvé, PhD
(California Institute of Technology)
Assistant Professor
Materials & Energy, Organic Chemistry, Physical Chemistry, Functional Polymers, Nanoscale Morphology, Organic Electronics, Solar Energy Conversion, Structure-Property Relationships

Daniel A. Scherson, PhD
(University of California, Davis)
Frank Hovorka Professor of Chemistry
Analytical Chemistry, Materials, Physical Chemistry, Photochemistry, Electrochemistry

Gregory P. Tochtrop, PhD
(Washington University Medical School)
Associate Professor
Biochemistry, Biophysical Chemistry, Chemical Biology, Medicinal Chemistry, Organic Chemistry, Bio-Organic Chemistry, Synthesis

Blanton S. Tolbert, PhD
(University of Rochester)
Assistant Professor
Biochemistry, Biophysical Chemistry, Structural Biology

Rajesh Viswanathan, PhD
(University of Indiana)
Assistant Professor
Organic Chemistry, Protein Biochemistry, Chemical Biology, Chemical Synthesis and Characterization, Genetically-Encoded Natural Products, Molecular Biology, Microbial Genetics, Bioinformatics, Metabolic Pathways, Drug Discovery

Michael G. Zagorski, PhD
(Case Western Reserve University)
Professor
Biochemistry, Biophysical Chemistry, Chemical Biology, Organic Chemistry, Beer Brewing, Bio-Organic Chemistry, Drug Delivery, NMR, Structural Biology


Lecturers

Raul E. Juarez Hernandez, PhD
(University of Notre Dame)
Full-time Lecturer
Organic Chemistry, Chemical Education

Rekha Srinivasan, PhD
(Case Western Reserve University)
Instructor
Analytical Chemistry, Organic Chemistry, Biophysical Chemistry

Richard H. West, PhD
(Case Western Reserve University)
Full-time Lecturer
Analytical Chemistry, Electrochemistry, Chemical Education


Research Faculty

Mikhail D. Linetsky, PhD
(Academy of Science of Ukraine)
Research Associate Professor
Biochemistry, Chemical Biology, Protein Chemistry, Post-Translational Protein Modification, Proteomics


Secondary Faculty

Paul Carey, PhD
(University of Sussex, UK)
Professor, Department of Biochemistry, School of Medicine
Biochemistry, Biophysical Chemistry, Microscopy / Imaging, Spectroscopy

John W. Crabb, PhD
(University of Kansas Medical Center)
Professor of Molecular Medicine, Cleveland Clinic Lerner College of Medicine, Case Western Reserve University
Proteomics of the visual cycle and age-related ocular diseases

Chris Dealwis, PhD
Associate Professor, Dept. Pharmacology
Biochemistry, Biophysics, Enzyme Catalysis, Pharmacology, Proteins

Thomas Gerken, PhD
(Case Western Reserve University)
Professor, Department of Pediatrics, School of Medicine
Biochemistry, Biophysical Chemistry, Chemical Biology, Glycosylation, Protein Chemistry, Protein Structure

Thomas Kelley, PhD
(University of Notre Dame)
Associate Professor, Department of Pediatrics, School of Medicine
Biochemistry, Medicinal Chemistry, Cellular Biology, Pharmacology

Zheng-Rong Lu, PhD
M. Frank and Margaret Domiter Rudy Professor of Biomedical Engineering
Drug Delivery, Molecular Imaging, Nanotechnology

John J. Mieyal, PhD
(Case Western Reserve University)
Professor, Department of Pharmacology, School of Medicine
Biochemistry, Chemical Biology, Medicinal Chemistry, Bio-Organic Chemistry, Catalysis, Cellular Biology, Molecular Biology, Neurochemistry, Pharmacology

Stuart J. Rowan, PhD
(University of Glasgow, UK)
Professor, Department of Macromolecular Science and Engineering, Case School of Engineering
Materials & Energy, Organic Chemistry, Photochemistry, Nanotechnology, Physical Organic Chemistry, Polymers, Supramolecular Chemistry, Synthesis

David Schiraldi, PhD
(University of Oregon)
Professor, Macromolecular Science & Engineering
Polymer synthesis and structure-property relationships, Condensation polymers, Polymer nanocomposites, Fuel cell durability, Polymerization catalysis, Transport phenomena and packaging applications, Polymer blends and complex polymer systems.

Witold K. Surewicz, PhD
(University of Lodz, Poland)
Professor, Department of Physiology and Biophysics, School of Medicine
Biochemistry, Biophysical Chemistry, Neurochemistry, Spectroscopy

Yanming Wang, PhD
(ETH Zürich, Switzerland)
Associate Professor of Radiology; Director of Radiopharmaceutical Division, Case Center for Imaging Research, School of Medicine
Organic synthesis; molecular probes for in vivo imaging


Adjunct Faculty

Ormond Brathwaite, PhD
(City University of New York)
Adjunct Associate Professor
Biochemistry

Michael J. Kenney, PhD
(Iowa State University)
Adjunct Associate Professor
Analytical Chemistry, Physical Chemistry, Chemical Education, Computer Programming, Application Development

M. Cather Simpson, PhD
(University of New Mexico)
Adjunct Associate Professor
Biophysical chemistry; spectroscopic studies of biologically significant processes


Emeritus Faculty

Robert C. Dunbar, PhD
(Stanford University)
Professor Emeritus of Chemistry
Chemical Biology, Biophysical Chemistry, Organometallic Chemistry, Photochemistry, Physical Chemistry, Astrochemistry, Chemical Kinetics, Computational Chemistry, Ion Chemistry, Spectroscopy, Theoretical Chemistry, Thermochemistry

Gilles Klopman, PhD
(University of Brussels)
Charles Frederic Mabery Professor Emeritus of Research in Chemistry
Biochemistry, Organic Chemistry, Bio-Organic Chemistry, Environmental Health Sciences, Medicinal Chemistry, Oncology, Theoretical Chemistry

Gheorghe D. Mateescu, PhD
(Case Western Reserve University)
Professor Emeritus of Chemistry
Analytical Chemistry, Physical Chemistry

Barry Miller, PhD
(Massachusetts Institute of Technology)
Frank Hovorka Professor Emeritus of Chemistry
Physical Chemistry, Electrochemistry

John E. Stuehr, PhD
(Western Reserve University)
Emeritus Professor
Biochemistry, Physical Chemistry, Biophysical Chemistry

Terry Swift, PhD
Professor Emeritus of Chemistry
Analytical Chemistry

Fred L. Urbach, PhD
(Michigan State University)
Professor Emeritus of Chemistry
Analytical Chemistry, Biochemistry, Inorganic Chemistry, Bio-Inorganic Chemistry, Catalysis

BS Chemistry  |  BA Chemistry  |  BA Chemical Biology  | Honors  | Teacher Licensure  |  Minor

Undergraduate Programs

Majors

The Department of Chemistry offers three curricula for undergraduate majors, leading to a Bachelor of Science (BS) degree in Chemistry, Bachelor of Arts degree (BA) in Chemistry, or Bachelor of Arts (BA) degree in Chemical Biology.

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Bachelor of Science in Chemistry Program

The BS program in Chemistry is designed for students who seek professional careers in the chemical sciences and is certified by the American Chemical Society. The BS curriculum provides a rigorous background in chemistry, yet offers considerable flexibility in the senior year in the choice of electives, allowing BS majors to pursue areas of chemistry of particular interest to them in greater depth. At least three units of research (CHEM 397 / CHEM 398) are required, and up to nine units of research may be credited toward the degree.

Total Units Required for Graduation: 120

Chemistry BS - Required Chemistry Courses

First YearUnits
FallSpring
Principles of Chemistry I (CHEM 105)3  
Principles of Chemistry Laboratory (CHEM 113)2  
Principles of Chemistry II (CHEM 106)  3
Year Total: 5 3
 
Second YearUnits
FallSpring
Organic Chemistry I (CHEM 323)3  
Organic Chemistry II (CHEM 324)  3
Laboratory Methods in Organic Chemistry (CHEM 322)  3
Year Total: 3 6
 
Third YearUnits
FallSpring
Quantitative Analysis Laboratory (CHEM 304)2  
Foundations of Analytical Chemistry (CHEM 310)3  
Physical Chemistry I (CHEM 335)3  
Physical Chemistry II (CHEM 336)  3
Laboratory Methods in Physical Chemistry (CHEM 332)  3
One of the following courses:  3-4
Introductory Biochemistry (CHEM 328) (spring, 3 units)
Chemical Aspects of Living Systems (CHEM 329) (fall, 3 units)
Introduction to Biochemistry: From Molecules To Medical Science (BIOC 307)
Year Total: 8 9-10
 
Fourth YearUnits
FallSpring
Inorganic Chemistry I (CHEM 311)3  
Laboratory Methods in Inorganic Chemistry (CHEM 331)3  
Undergraduate Research (CHEM 397)3-6  
Chemistry elective3  
Undergraduate Research/Senior Capstone Project (CHEM 398)  3 - 6
Chemistry elective  3
Year Total: 12-15 6-9
 
Total Units in Sequence:  52-59

 

Chemistry BS - Additional Required Courses

MATH 121Calculus for Science and Engineering I4
MATH 122Calculus for Science and Engineering II4
or MATH 124 Calculus II
MATH 223Calculus for Science and Engineering III3
or MATH 227 Calculus III
One of the following:3
Elementary Differential Equations
Differential Equations
Basic Statistics for Engineering and Science
PHYS 121General Physics I - Mechanics4
or PHYS 123 Physics and Frontiers I - Mechanics
PHYS 122General Physics II - Electricity and Magnetism4
or PHYS 124 Physics and Frontiers II - Electricity and Magnetism
PHYS 221Introduction to Modern Physics3
Six additional units of approved technical electives, which may include up to six units of the following:6
Undergraduate Research
Undergraduate Research/Senior Capstone Project
Total Units31

The chemistry electives may include any chemistry department course at the 300 level or above which is not part of the "core set," or selected courses with a strong chemistry content at the 300 level or above from other science departments. Only three units of CHEM 397 may be applied to a chemistry elective.

The technical electives may be chosen more widely from any of the physical sciences, math, or engineering courses. An additional six units of CHEM 397 may be taken as technical electives. Further additional units of CHEM 397 may be taken as Free Electives. Students may wish to group their electives into "tracks" of specialization in order to tailor their degree to a particular area of chemistry.

BS majors who plan to go on to graduate study may elect to take advanced courses in:

Inorganic Chemistry
Advanced Inorganic Chemistry I
Organic Chemistry
Advanced Organic Chemistry I
Advanced Organic Chemistry II
Synthetic Methods in Organic Chemistry
Physical Chemistry
Chemical Kinetics
Chemical Thermodynamics
Quantum Mechanics I

Students can also elect to take other graduate offerings. Interdisciplinary strengths can be achieved by selecting technical electives in biochemistry, biomedical engineering, chemical engineering, macromolecular science, and materials science as well as in biology, geological sciences, mathematics, physics, and statistics.


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Bachelor of Arts in Chemistry Program

The BA program in Chemistry is intended for pre-professional students who plan careers in medicine, dentistry, veterinary medicine, pharmacy, or in other fields for which a baccalaureate degree in chemistry provides appropriate training. BA majors may supplement their required courses with additional chemistry courses or may utilize the curriculum’s flexibility to develop an interdisciplinary program of their choice. Many Chemistry BA majors participate in undergraduate research within the Department of Chemistry (CHEM 397 / CHEM 398) or in other science departments, including those in the medical school.

Total Units Required for Graduation:  120

Chemistry BA - Required Chemistry Courses

First YearUnits
FallSpring
Principles of Chemistry I (CHEM 105)3  
Principles of Chemistry Laboratory (CHEM 113)2  
Principles of Chemistry II (CHEM 106)  3
Year Total: 5 3
 
Second YearUnits
FallSpring
Introductory Organic Chemistry I (CHEM 223)
or Organic Chemistry I (CHEM 323)
3  
Introductory Organic Chemistry Laboratory I (CHEM 233)2  
Introductory Organic Chemistry II (CHEM 224)
or Organic Chemistry II (CHEM 324)
  3
Introductory Organic Chemistry Laboratory II (CHEM 234)
or Laboratory Methods in Organic Chemistry (CHEM 322)
  2-3
Year Total: 5 5-6
 
Third YearUnits
FallSpring
Introductory Physical Chemistry I (CHEM 301)
or Physical Chemistry I (CHEM 335)
3  
Quantitative Analysis Laboratory (CHEM 304)2  
Foundations of Analytical Chemistry (CHEM 310)3  
Introductory Physical Chemistry II (CHEM 302)
or Physical Chemistry II (CHEM 336)
  3
Introductory Physical Chemistry Laboratory (CHEM 305)  3
Year Total: 8 6
 
Fourth YearUnits
FallSpring
Electives
Year Total:    
 
Total Units in Sequence:  32-33

 

Chemistry BA - Additional Required Courses

PHYS 115Introductory Physics I4
or PHYS 121 General Physics I - Mechanics
PHYS 116Introductory Physics II4
or PHYS 122 General Physics II - Electricity and Magnetism
MATH 125Math and Calculus Applications for Life, Managerial, and Social Sci I4
or MATH 121 Calculus for Science and Engineering I
MATH 126Math and Calculus Applications for Life, Managerial, and Social Sci II4
or MATH 122 Calculus for Science and Engineering II
Total Units16

 


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Bachelor of Arts in Chemical Biology Program

The BA program in Chemical Biology is intended for pre-professional students who plan careers in medicine, dentistry, veterinary medicine, pharmacy, or for individuals seeking careers that utilize chemistry to solve problems affecting living systems.  A key component of the major is the flexibility imparted by fewer required courses and the integration of six credit hours of technical electives.  Many Chemical Biology BA majors participate in undergraduate research within the Department of Chemistry (CHEM 397 / CHEM 398) or in other science departments, including those in the medical school.

Total Units Required for Graduation:  120

Chemical Biology BA - Required Chemistry Courses

First YearUnits
FallSpring
Principles of Chemistry I (CHEM 105)3  
Principles of Chemistry II (CHEM 106)  3
Principles of Chemistry Laboratory (CHEM 113)  2
Year Total: 3 5
 
Second YearUnits
FallSpring
Introductory Organic Chemistry Laboratory I (CHEM 233)
or Laboratory Methods in Organic Chemistry (CHEM 322)
2-3  
Organic Chemistry I (CHEM 323)3  
Chemical Biology Lab (CHEM 306)  3
Introductory Biochemistry (CHEM 328)  3
Year Total: 5-6 6
 
Third YearUnits
FallSpring
Introductory Physical Chemistry I (CHEM 301)
or Physical Chemistry I (CHEM 335)
3  
Quantitative Analysis Laboratory (CHEM 304)2  
Foundations of Analytical Chemistry (CHEM 310)3  
Year Total: 8  
 
Fourth YearUnits
FallSpring
Undergraduate Research/Senior Capstone Project (CHEM 398)  3 - 6
Year Total:   3-6
 
Total Units in Sequence:  30-34

 

Chemical Biology BA - Additional Required Courses

Course List

BIOL 214Genes, Evolution and Ecology3
BIOL 214LGenes, Evolution and Ecology Lab1
BIOL 215Cells and Proteins3
BIOL 215LCells and Proteins Laboratory1
PHYS 115Introductory Physics I4
or PHYS 121 General Physics I - Mechanics
PHYS 116Introductory Physics II4
or PHYS 122 General Physics II - Electricity and Magnetism
MATH 125Math and Calculus Applications for Life, Managerial, and Social Sci I4
or MATH 121 Calculus for Science and Engineering I
MATH 126Math and Calculus Applications for Life, Managerial, and Social Sci II4
or MATH 122 Calculus for Science and Engineering II
Six additional units of approved technical electives6
Total Units30

 


Departmental Honors

Chemistry majors who have excellent academic records may participate in the Honors in Chemistry program. To graduate with honors in chemistry, a student must satisfy the following requirements:

  1. A combined grade point average of 3.50 in chemistry, physics, and mathematics and an overall grade point average of 3.20

  2. A minimum of six units of Undergraduate Research (CHEM 397), or chemical research done under another course number with departmental approval

  3. A thesis approved by the department’s undergraduate affairs committee based on the level of research, quality of the manuscript, and chemical content

     


Teacher Licensure in Chemistry                       

The Chemistry Department offers a special option for undergraduate students who wish to pursue a Chemistry major and a career in teaching.  The Adolescent to Young Adult (AYA) Teacher Education Program in Physical Sciences prepares CWRU students to receive an Ohio Teaching License for grades 7-12.  Students declare a second major in Education – which involves 34 hours in Education and practicum requirements – and complete a planned sequence of Chemistry content coursework within the context of the BA Chemistry major.  The program is designed to offer several unique features not found in other programs and to place students in mentored teaching situations throughout their teacher preparation career.  This small, rigorous program is designed to capitalize on the strengths of CWRU’s Chemistry Department, its Teacher Education Program, and the relationships the University has built with area schools.


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Chemistry Minor

Students may complete a minor in chemistry, defined as one year of freshman chemistry (including laboratory); two additional three-unit lecture courses; and two additional laboratory or approved courses. A recommended sequence would include:

Course List

CHEM 105Principles of Chemistry I3
CHEM 106Principles of Chemistry II3
CHEM 113Principles of Chemistry Laboratory2
CHEM 223Introductory Organic Chemistry I3
or CHEM 323 Organic Chemistry I
CHEM 224Introductory Organic Chemistry II3
or CHEM 324 Organic Chemistry II
CHEM 233Introductory Organic Chemistry Laboratory I2
CHEM 234Introductory Organic Chemistry Laboratory II2
Total Units18

Other sequences may be followed after consultation with the Department of Chemistry.

BS Chemistry  |  BA Chemistry  |  BA Chemical Biology  | Honors  | Teacher Licensure  |  Minor

Graduate Programs

Master of Science Programs

The MS degree in chemistry may be obtained by completing (1) a program that includes the preparation of a master’s thesis, or (2) a program involving only course work. Both programs require a minimum of 27 units, of which up to six units may be for the master’s thesis. Course work for the master’s degree may be taken on a part-time basis, but thesis research can be undertaken only by full-time graduate students. Thus, only the master’s degree without thesis can be earned entirely on a part-time basis.

The Science and Technology Entrepreneurship Program (STEP) is a three- or four-semester professional MS degree offered in chemistry as well as in biotechnology and physics. Students enter the Chemistry Entrepreneurship program with a bachelor’s, master’s, or doctoral degree in a chemistry-related field. The program consists of advanced courses in chemistry, business, and technology innovation and an entrepreneurial project with technical content in an existing company or new venture.

Doctor of Philosophy Program

The PhD degree in chemistry is granted to those students who have shown an extensive knowledge of advanced chemistry and the ability to do original research. The program usually requires four years of full-time study after the bachelor’s degree. Besides advanced courses, the program consists of cumulative and oral examinations, seminars and colloquia, and an original research project. At least twelve months must be spent in residence on campus while fulfilling the PhD thesis research requirement.

Full-time graduate students who maintain satisfactory academic performance while pursuing the PhD degree in chemistry normally receive a stipend for teaching and/or research, which includes full tuition and a monthly amount sufficient to cover living expenses.

Research

The Department of Chemistry is noted for research programs in (1) chemical biology and (2) energy and materials. Projects range from synthetic studies of important bioactive substances, including antibiotics and DNA-binding substances, to detailed examination of the surface properties of materials used in batteries and electrolytic cells. Studies are being performed with molecules as simple as oxygen and as complicated as those which describe the active centers of enzymes or the protein core of insoluble aggregates that deposit in neurodegenerative disease. Efforts are being made to understand the basic chemical properties leading to reactive mediators generated from physiological lipids.

Other research is aimed at developing new drugs for photodynamic therapy and at understanding the mechanism of action of drugs for antiretroviral therapy. The influence of metal ions in modifying reactivity is a common interest of several members of the faculty, as is the development of organometallic compounds for materials and catalysis. Chemical surfaces are being studied, as are various applications of nanoparticles, from cells to the environment. Studies designed to characterize electrode-electrolyte interfaces, the electrochemical properties of new semiconductors, and single-cell microelectrodes are also ongoing. These efforts are complemented by theoretical studies on the interfacial structure and bonding of composite materials.

Case Western Reserve University ranks among the leading universities internationally in its strengths in electrochemistry and has brought these strengths together in the Yeager Center for Electrochemical Studies (YCES). The interdisciplinary nature of electrochemistry involves the interaction of electrochemists in the chemistry and chemical engineering departments with metallurgists, surface physicists, inorganic and organic chemists, polymer membrane chemists, and electrical engineers. Such interactions, lacking on most campuses, are promoted at Case Western Reserve University through YCES. Graduate students in the chemistry department have the opportunity to specialize in electrochemistry in one of the most extensive course and research programs in the United States.

Colloquia and Seminars

The department sponsors a rich program of colloquia and seminars on recent advances in chemical research. Most notable among these is the Frontiers in Chemistry Lecture Series, in which scientists of international distinction lecture on major discoveries and developments in chemistry. In addition, a weekly colloquium series provides lectures by invited speakers in a variety of fields of chemical investigation. Both of these programs are addressed to an audience of faculty, graduate students, and other chemical scientists in the university and the Cleveland area, and are a vital means to broaden current knowledge. Numerous other seminars and meetings are held on a more specialized and informal level. Most individual research groups conduct weekly discussions to evaluate their progress.

Courses

CHEM 102. The Molecules of Medicine. 1 Unit.

The central tenet of CHEM 102 is the identification and presentation of concrete examples to illustrate how basic scientific principles impact medicine in a substantive way. Several topics will be addressed that include medical diagnostics, medical instrument design, and drug development. An emphasis of this class will be to convey how topics being presented in other classes in the pre-medical curriculum have a direct and substantive impact on the practice of medicine.

CHEM 105. Principles of Chemistry I. 3 Units.

Atomic structure; thermochemistry; periodicity, bonding and molecular structure; intermolecular forces; properties of solids; liquids, gases and solutions. Recommended preparation: One year of high school chemistry.

CHEM 106. Principles of Chemistry II. 3 Units.

Thermodynamics, chemical equilibrium; acid/base chemistry; oxidation and reduction; kinetics; spectroscopy; introduction to nuclear, organic, inorganic, and polymer chemistry. Prereq: CHEM 105 or equivalent.

CHEM 111. Principles of Chemistry for Engineers. 4 Units.

A first course in university chemistry emphasizing chemistry of materials for engineering students. Atomic theory and quantitative relationships; gas laws and kinetic theory; solutions, acid-base properties and pH; thermodynamics and equilibrium; kinetics, catalysis, and mechanisms; molecular structure and bonding. Recommended preparation: One year of high school chemistry or permission of department.

CHEM 113. Principles of Chemistry Laboratory. 2 Units.

A one semester laboratory based on quantitative chemical measurements. Experiments include analysis, synthesis and characterization, thermochemistry and chemical kinetics. Computer analysis of data is a key part of all experiments. Prereq or Coreq: CHEM 105 or CHEM 106 or CHEM 111 or ENGR 145.

CHEM 114. Chemistry Frontiers Laboratory. 2 Units.

An introduction to laboratory techniques and computer-based methods for chemical research for the chemistry major. Scientific information databases, structural chemistry, experimental design and data handling, chemical synthesis and characterization. Prereq: CHEM 105 or CHEM 111, and CHEM 113. Coreq: CHEM 106.

CHEM 223. Introductory Organic Chemistry I. 3 Units.

Introductory course for science majors and engineering students. Develops themes of structure and bonding along with elementary reaction mechanisms. Includes treatment of hydrocarbons, alkyl halides, alcohols, and ethers as well as an introduction to spectroscopy. Prereq: CHEM 106 or CHEM 111.

CHEM 224. Introductory Organic Chemistry II. 3 Units.

Continues and extends themes of structure and bonding from CHEM 223 and continues spectroscopy and more complex reaction mechanisms. Includes treatment of aromatic rings, carbonyl compounds, amines, and selected special topics. Prereq: CHEM 223 or CHEM 323.

CHEM 233. Introductory Organic Chemistry Laboratory I. 2 Units.

An introductory organic laboratory course emphasizing microscale operations. Synthesis and purification of organic compounds, isolation of natural products, and systematic identification of organic compounds by physical and chemical methods. Prereq: CHEM 106 or CHEM 111 and CHEM 113 or equivalent. Coreq: CHEM 223 or CHEM 323.

CHEM 234. Introductory Organic Chemistry Laboratory II. 2 Units.

A continuation of CHEM 233, involving multi-step organic synthesis, peptide synthesis, product purification and analysis using sophisticated analytical techniques such as chromatography and magnetic resonance spectroscopy. Prereq: CHEM 233. Coreq: CHEM 224

CHEM 290. Chemical Laboratory Methods for Engineers. 3 Units.

Techniques of chemical synthesis, analysis, and characterization. Uses students' backgrounds in general and organic chemistry, but requires no background in chemical laboratory operations. Prereq or Coreq: CHEM 223 or CHEM 323.

CHEM 301. Introductory Physical Chemistry I. 3 Units.

First of a two-semester sequence covering principles and applications of physical chemistry, intended for chemistry and engineering majors and other students having primary interests in biochemical, biological or life-science areas. States and properties of matter. Thermodynamics and its application to chemical and biochemical systems. Chemical equilibrium. Electrochemistry. Recommended preparation: One year each of undergraduate physics and calculus, preferably including partial derivatives. Prereq: CHEM 106 or equivalent.

CHEM 302. Introductory Physical Chemistry II. 3 Units.

Continuation of CHEM 301. Chemical kinetics and catalysis. Introductory quantum chemistry. Spectroscopy. Statistical thermodynamics. Prereq CHEM 301 or CHEM 335.

CHEM 304. Quantitative Analysis Laboratory. 2 Units.

A one-semester laboratory course providing practical experience in the analytical process. Focus is on statistical error analysis of measurements, method validation and instrument calibration, and reporting. Basic laboratory skills are developed and evaluated based on accuracy and precision of measurements. Experiments using titration, spectroscopy, electrochemistry, liquid and gas chromatography, and mass spectrometry are conducted. Prereq: CHEM 106 and CHEM 113. Coreq: CHEM 310.

CHEM 305. Introductory Physical Chemistry Laboratory. 3 Units.

A one-semester laboratory course focusing on the principles and quantitative characterization of chemical and biochemical systems. Experiments include chemical equilibrium kinetics, electrochemistry, spectroscopy and the use of computers for the statistical analysis of experimental data. Seminar discussions and disciplinary writing of results. Counts as SAGES Departmental Seminar. Prereq: CHEM 301 and CHEM 304 or CHEM 335. Or Prereq or Coreq: CHEM 302 or CHEM 336.

CHEM 306. Chemical Biology Lab. 3 Units.

A one semester laboratory and lecture course developed to introduce students to a variety of chemical biology laboratory themes including buffering, identification of amino acids, immunoassay, ligand binding, cellular fractionation, enzyme isolation and purification, proteomics, and enzyme kinetics. Techniques include titration, various forms of chromatography, colorimetric assays, electrophoresis, high performance liquid chromatography and liquid chromatography coupled with tandem mass spectrometry. Prereq: CHEM 233.

CHEM 310. Foundations of Analytical Chemistry. 3 Units.

A one-semester lecture covering classical and modern aspects of the analytical process; analysis requirements, method selection including capabilities and limitations, sampling and sample processing, measurement data statistics for evaluation of precision and accuracy, method validation, and reporting. Fundamental concepts in equilibrium thermodynamics are covered in the context of chemical analysis. Methods based on titration, spectroscopy, electrochemistry, chromatography, and mass spectrometry are emphasized. Prereq: CHEM 106 and CHEM 113. Coreq: CHEM 304.

CHEM 311. Inorganic Chemistry I. 3 Units.

Fundamentals of inorganic chemistry. Topics include molecular structure, molecular shape and symmetry, structure of solids, d-metal complexes, oxidation and reduction, and acids and bases. Prereq or Coreq: CHEM 301 or CHEM 335.

CHEM 312. Inorganic Chemistry II. 3 Units.

Continuation of CHEM 311. Fundamentals of inorganic chemistry. Topics include electronic spectra of complexes, structures and properties of solids, organometallic compounds, and descriptive chemistry of representative elements. Prereq: CHEM 311.

CHEM 322. Laboratory Methods in Organic Chemistry. 3 Units.

Experimental approach to the synthesis, purification and characterization of organic compounds. Nuclear magnetic resonance (NMR) and infrared (IR) spectroscopies; chromatographic techniques. Prereq: CHEM 304 and CHEM 223 or CHEM 323. Prereq or Coreq: CHEM 224 or CHEM 324.

CHEM 323. Organic Chemistry I. 3 Units.

Relationships between molecular structure and chemical reactivity and development of sophisticated problem-solving skills in the context of organic reaction mechanisms and multi-step synthesis. Homolytic and heterolytic substitution, elimination, oxidation and reduction reactions; topics in stereochemistry and spectroscopy. Recommended for chemistry, biochemistry, and related majors. Prereq: CHEM 106 or equivalent.

CHEM 324. Organic Chemistry II. 3 Units.

Continuation of CHEM 323. Introduces the chemistry of carbonyl, aromatic and amino functional groups, and develops the concepts of conjugation and resonance, molecular orbital theory and pericyclic reactions. Prereq: CHEM 223 or CHEM 323.

CHEM 325. Physical Methods for Determining Organic Structure. 3 Units.

Structure determination of organic compounds using mass spectrometry and modern instrumental techniques such as infrared, ultraviolet, visible, and nuclear magnetic resonance spectroscopy. Recommended preparation: Two semesters of undergraduate organic chemistry. Offered as CHEM 325 and CHEM 425.

CHEM 328. Introductory Biochemistry. 3 Units.

A survey of biochemistry with a strong emphasis on the chemical logic underlying metabolic pathways and the evolution of biomolecules. Cellular architecture. Amino acids and protein structure, purification, analysis, and synthesis. DNA, RNA, the flow of genetic information, and molecular biological technology. Enzyme kinetics, catalytic, and regulatory strategies. Sugars, complex carbohydrates, and glycoproteins. Lipids and cell membranes. Glycolysis, gluconeogenesis, carbon fixation through the "dark reactions" of photosynthesis, aerobic catabolism through the citric acid cycle, and glycogen metabolism. Biosynthesis and degradation of fatty acids, amino acids, and proteins. Offered as CHEM 328 and CHEM 428. Prereq: CHEM 224 or CHEM 324.

CHEM 329. Chemical Aspects of Living Systems. 3 Units.

A survey of biochemical systems exploring their molecular circuitry and architecture. Protein structure and function. Lipids, cell membranes, channels and pumps. Redox processes and electron transport. Lipid and carbohydrate metabolism, its control, reciprocal regulation, and global integration. Nucleotide biosynthesis, DNA replication, recombination, and repair. RNA synthesis, splicing, and translation: protein synthesis and the control of gene expression. Sensory and immune systems. Molecular motors. Recommended preparation: Two semesters of undergraduate organic chemistry and one semester of undergraduate physical chemistry. Offered as CHEM 329 and CHEM 429.

CHEM 331. Laboratory Methods in Inorganic Chemistry. 3 Units.

Synthesis, separation techniques, physical properties, and analysis. Advanced techniques of chemical synthesis, leading the student to the preparation of interesting inorganic and organometallic compounds. Prereq: CHEM 322.

CHEM 332. Laboratory Methods in Physical Chemistry. 3 Units.

Modern techniques of physicochemical measurement, including, kinetics, spectroscopy, and electrochemistry and the use of statistical methods for the analysis of experimental data. Seminar discussions and disciplinary writing of results. Counts as SAGES Departmental Seminar. Prereq: CHEM 304. Prereq or Coreq: CHEM 336.

CHEM 333. Medicinal Chemistry and Drug Development. 3 Units.

This course provides an overview on how principles in chemistry and biology are integrated to facilitate drug development. Primary emphasis will be placed on the development of organic molecules as drugs and metabolic enzymes as drug targets. Subjects pertinent to the introduction of medicinal chemistry, evaluation of drug efficacies in vitro and in vivo, and drug metabolism will be covered. Offered as CHEM 333 and CHEM 433. Prereq: CHEM 223 or CHEM 323 and BIOL 215. Coreq: CHEM 224 or CHEM 324.

CHEM 335. Physical Chemistry I. 3 Units.

First of a two-semester sequence of physical chemistry for chemistry majors and others with career goals in the physical sciences or engineering. States of matter. Kinetic theory of gases. Transport phenomena. Chemical thermodynamics and its application to chemical systems. Equilibrium. Ionic solutions and electrochemistry. Introduction to chemical kinetics. Recommended preparation: One year each of undergraduate physics and calculus, including partial derivatives. Prereq: CHEM 106 or equivalent.

CHEM 336. Physical Chemistry II. 3 Units.

Continuation of CHEM 335. Reaction kinetics and catalysis. Reaction dynamics. Chemical quantum mechanics. Statistical mechanics and thermodynamics. Spectroscopy. Prereq: CHEM 335 or Chemical Engineering Major with at least Junior standing.

CHEM 337. Quantum Mechanics I. 3 Units.

Introduction to quantization, measurement and the Schrodinger equation; angular momentum and states of molecules. Perturbation theory, spectroscopy and chemical bonding. Variational theory and calculations of molecular properties. Offered as CHEM 335 and CHEM 446. Prereq: CHEM 336.

CHEM 339. Bioinorganic Chemistry. 3 Units.

An introduction to metal ions in biology and medicine. Topics of emphasis include metalloenzymes, inorganic elements in pharmaceuticals, and physical methods of characterization in biology. Course material will be presented through a seminar format, and will involve extensive class participation, student presentations, and literature research reports. Offered as CHEM 339 and CHEM 439. Prereq: CHEM 224 or CHEM 324

CHEM 340. Solar Energy Conversion. 3 Units.

This is a multidisciplinary course from a chemist's point of view. This course teaches the background necessary to read and understand the scientific literature on solar energy conversion, and includes some basic device physics, materials chemistry and chemistry. Topics provide an overview of the field and includes: Global energy perspective, principles of photovoltaics, crystalline solar cells, thin-film solar cells, dye-sensitized solar cells, organic solar cells (with emphasis on polymer-based solar cells), photoelectrochemical cells and artificial photosynthesis for fuel production, and semiconductor nanostructures and quantum dots for solar energy conversion. The course includes three laboratories and a demo using state-of-the-art equipment, as well as presentations of recent research articles by the graduate students. It is recommended that students have experience with thermodynamics. The following CWRU courses would meet this expectation: CHEM 301, CHEM 335, ENGR 225 or PHYS 313. Offered as CHEM 340 and CHEM 440. Prereq: CHEM 106 or ENGR 145.

CHEM 341. Functional Nanomaterials. 3 Units.

This course is designed to introduce important concepts on the fundamental physical and chemical properties of technologically important nanometer scale materials. The course will cover an overview of the scientific principles pertaining to new properties at the nanoscale; synthesis and characterization tools; and existing and emerging applications of nanomaterials. It will center on current research developments on major classes of functional nanomaterials, including plasmonic nanoparticles, quantum dots, nanomagnets, carbon nanotubes, nanocatalysts and hybrid inorganic/organic nanostructures. In addition an emphasis will be placed on understanding the broader societal, economical and environmental impact of the scientific and technological advances brought forward by nanotechnology. Offered as CHEM 341 and CHEM 441.

CHEM 395. Chemistry Colloquium Series. 1 Unit.

Course content provided by Thursday chemistry department colloquia (or Frontiers in Chemistry lectures). Discussion sessions review previous lectures and lay foundation for forthcoming lectures.

CHEM 397. Undergraduate Research. 1 - 6 Unit.

Independent research project within a research group in the chemistry department or, by petition, within a research group in another Case department. Arrangements should be made with the faculty member selected. Open to all chemistry majors and other qualified students; required for Honors in Chemistry. A written report is required each semester.

CHEM 398. Undergraduate Research/Senior Capstone Project. 3 - 6 Units.

Independent research project within a research group in the chemistry department or, by petition, within a research group in another Case department. Arrangements should be made by consultation with the faculty member selected and the Senior Capstone Committee of the chemistry department. Open to all chemistry majors and other qualified students. Satisfies the research requirement for Honors in Chemistry. A written report and public oral presentations are required. Counts as SAGES Senior Capstone.

CHEM 406. Chemical Kinetics. 3 Units.

Theory and characterization of chemical rate processes. Recommended preparation: Two semesters of undergraduate physical chemistry.

CHEM 407. Chemical Thermodynamics. 3 Units.

Thermodynamics and statistical thermodynamics and their application to chemical problems. Recommended preparation: Two semesters of undergraduate physical chemistry.

CHEM 408. Advanced Physical Chemistry. 3 Units.

Topics in physical chemistry, intended for entering graduate students, giving background tools appropriate for graduate research in areas of chemistry other than physical chemistry. Illustrations from the contemporary chemical research literature will be emphasized. Thermodynamics and statistical mechanics, quantum chemistry and computation, spectroscopy, and chemical kinetics and dynamics. Recommended preparation: One year of undergraduate physical chemistry.

CHEM 412. Advanced Inorganic Chemistry I. 3 Units.

Chemistry of inorganic systems. Spectroscopy, magnetism, and stereochemistry of transition metal compounds. Recommended preparation: One semester of undergraduate inorganic chemistry and two semesters of undergraduate physical chemistry.

CHEM 414. Organometallic Reactions and Structures. 3 Units.

Bonding, structure, and mechanistic aspects of organometallic chemistry and the relevance of organometallic species to chemical catalysis. Recommended preparation: One semester of undergraduate inorganic chemistry.

CHEM 421. Advanced Organic Chemistry I. 3 Units.

Structure, bonding, and molecular orbital theory. Stereochemistry and conformational analysis. Reaction mechanisms. Aromaticity and aromatic substitution. Pericyclic reactions, orbital symmetry conservation, and free radical chemistry. Recommended preparation: Two semesters of undergraduate organic chemistry.

CHEM 422. Advanced Organic Chemistry II. 3 Units.

Carbocations and carbanions. Nucleophilic and electrophilic aliphatic substitutions. Heterolytic addition and elimination reactions. Carbonyl reactions. Acyl transfer chemistry. Oxidations, reductions, and rearrangements. Prereq: CHEM 421 or consent of instructor.

CHEM 425. Physical Methods for Determining Organic Structure. 3 Units.

Structure determination of organic compounds using mass spectrometry and modern instrumental techniques such as infrared, ultraviolet, visible, and nuclear magnetic resonance spectroscopy. Recommended preparation: Two semesters of undergraduate organic chemistry. Offered as CHEM 325 and CHEM 425.

CHEM 428. Introductory Biochemistry. 3 Units.

A survey of biochemistry with a strong emphasis on the chemical logic underlying metabolic pathways and the evolution of biomolecules. Cellular architecture. Amino acids and protein structure, purification, analysis, and synthesis. DNA, RNA, the flow of genetic information, and molecular biological technology. Enzyme kinetics, catalytic, and regulatory strategies. Sugars, complex carbohydrates, and glycoproteins. Lipids and cell membranes. Glycolysis, gluconeogenesis, carbon fixation through the "dark reactions" of photosynthesis, aerobic catabolism through the citric acid cycle, and glycogen metabolism. Biosynthesis and degradation of fatty acids, amino acids, and proteins. Offered as CHEM 328 and CHEM 428.

CHEM 429. Chemical Aspects of Living Systems. 3 Units.

A survey of biochemical systems exploring their molecular circuitry and architecture. Protein structure and function. Lipids, cell membranes, channels and pumps. Redox processes and electron transport. Lipid and carbohydrate metabolism, its control, reciprocal regulation, and global integration. Nucleotide biosynthesis, DNA replication, recombination, and repair. RNA synthesis, splicing, and translation: protein synthesis and the control of gene expression. Sensory and immune systems. Molecular motors. Recommended preparation: Two semesters of undergraduate organic chemistry and one semester of undergraduate physical chemistry. Offered as CHEM 329 and CHEM 429.

CHEM 430. Advanced Methods in Structural Biology. 1 - 6 Unit.

The course is designed for graduate students who will be focusing on one or more methods of structural biology in their thesis project. This course is divided into 3-6 sections (depending on demand). The topics offered will include X-ray crystallography, nuclear magnetic resonance spectroscopy, optical spectroscopy, mass spectrometry, cryo-electron microscopy, and computational and design methods. Students can select one or more modules. Modules will be scheduled so that students can take all the offered modules in one semester. Each section is given in 5 weeks and is worth 1 credit. Each section covers one area of structural biology at an advanced level such that the student is prepared for graduate level research in that topic. Offered as BIOC 430, CHEM 430, PHOL 430, and PHRM 430.

CHEM 433. Medicinal Chemistry and Drug Development. 3 Units.

This course provides an overview on how principles in chemistry and biology are integrated to facilitate drug development. Primary emphasis will be placed on the development of organic molecules as drugs and metabolic enzymes as drug targets. Subjects pertinent to the introduction of medicinal chemistry, evaluation of drug efficacies in vitro and in vivo, and drug metabolism will be covered. Offered as CHEM 333 and CHEM 433.

CHEM 435. Synthetic Methods in Organic Chemistry. 3 Units.

Systematic consideration of reactions involving functional group transformations and carbon-carbon bond formations used in modern organic synthesis. Recommended preparation: Two semesters of undergraduate organic chemistry.

CHEM 436. Complex Molecular Synthesis. 3 Units.

An advanced organic chemistry course providing students with an in-depth examination of the art of total synthesis drawing from both classical and recent examples. Recommended preparation: Two semesters of undergraduate organic chemistry.

CHEM 439. Bioinorganic Chemistry. 3 Units.

An introduction to metal ions in biology and medicine. Topics of emphasis include metalloenzymes, inorganic elements in pharmaceuticals, and physical methods of characterization in biology. Course material will be presented through a seminar format, and will involve extensive class participation, student presentations, and literature research reports. Offered as CHEM 339 and CHEM 439. Prereq: Graduate standing.

CHEM 440. Solar Energy Conversion. 3 Units.

This is a multidisciplinary course from a chemist's point of view. This course teaches the background necessary to read and understand the scientific literature on solar energy conversion, and includes some basic device physics, materials chemistry and chemistry. Topics provide an overview of the field and includes: Global energy perspective, principles of photovoltaics, crystalline solar cells, thin-film solar cells, dye-sensitized solar cells, organic solar cells (with emphasis on polymer-based solar cells), photoelectrochemical cells and artificial photosynthesis for fuel production, and semiconductor nanostructures and quantum dots for solar energy conversion. The course includes three laboratories and a demo using state-of-the-art equipment, as well as presentations of recent research articles by the graduate students. It is recommended that students have experience with thermodynamics. The following CWRU courses would meet this expectation: CHEM 301, CHEM 335, ENGR 225 or PHYS 313. Offered as CHEM 340 and CHEM 440.

CHEM 441. Functional Nanomaterials. 3 Units.

This course is designed to introduce important concepts on the fundamental physical and chemical properties of technologically important nanometer scale materials. The course will cover an overview of the scientific principles pertaining to new properties at the nanoscale; synthesis and characterization tools; and existing and emerging applications of nanomaterials. It will center on current research developments on major classes of functional nanomaterials, including plasmonic nanoparticles, quantum dots, nanomagnets, carbon nanotubes, nanocatalysts and hybrid inorganic/organic nanostructures. In addition an emphasis will be placed on understanding the broader societal, economical and environmental impact of the scientific and technological advances brought forward by nanotechnology. Offered as CHEM 341 and CHEM 441.

CHEM 445. Electrochemistry I. 3 Units.

Electrochemical properties and processes of electrode/electrolyte interfaces. Fundamental background for work in corrosion, electrodeposition, industrial electrolysis, electro-organic synthesis, batteries, fuel cells, and photoelectrochemical energy conversion. Recommended preparation: One semester of undergraduate physical chemistry.

CHEM 446. Quantum Mechanics I. 3 Units.

Introduction of quantization, measurement and the Schrodinger equation; angular momentum and states of molecules. Perturbation theory, spectroscopy and chemical bonding. Variational theory and calculations of molecular properties. Recommended preparation: Two semesters of undergraduate physical chemistry. Offered as CHEM 335 and CHEM 446.

CHEM 447. Quantum Mechanics II. 3 Units.

Continuation of CHEM 446. Ab initio and semi-empirical methods, configuration interactions, time dependent phenomena, and introduction to band theory of solids. Prereq: CHEM 446.

CHEM 450. Molecular Spectroscopy. 3 Units.

Translation, rotation, vibration, and electronic transitions of molecules. Prereq: CHEM 446.

CHEM 475. Protein Biophysics. 3 Units.

This course focuses on in-depth understanding of the molecular biophysics of proteins. Structural, thermodynamic and kinetic aspects of protein function and structure-function relationships will be considered at the advanced conceptual level. The application of these theoretical frameworks will be illustrated with examples from the literature and integration of biophysical knowledge with description at the cellular and systems level. The format consists of lectures, problem sets, and student presentations. A special emphasis will be placed on discussion of original publications. Offered as BIOC 475, CHEM 475, PHOL 475, PHRM 475, and NEUR 475.

CHEM 491. Modern Chemistry for Innovation I. 3 Units.

The first half of a two-semester sequence providing an understanding of chemistry as a basis for successfully launching new high-tech ventures. The course will examine physical limitations to present technologies and the use of chemistry to identify potential opportunities for new venture creation. The course will provide experience in using chemistry for both identification of incremental improvements and as the basis for alternative technologies. Case studies will be used to illustrate recent commercially successful (and unsuccessful) venture creation and will illustrate characteristics for success. Admission to this course requires consent of the department.

CHEM 492. Modern Chemistry for Innovation II. 3 Units.

Continuation of CHEM 491, with an emphasis on current and prospective opportunities for Chemistry Entrepreneurship. Longer term opportunities for Chemistry Entrepreneurship in emerging areas, including (but not be limited to) biomaterials, pharmacogenomics, biocatalysis, and drug discovery. Prereq: CHEM 491.

CHEM 493. Feasibility and Technology Analysis. 3 Units.

This course provides the tools scientists need to determine whether a technology is ready for commercialization. These tools include (but are not limited to): financial analysis, market analysis, industry analysis, technology analysis, intellectual property protection, the entrepreneurial process and culture, an introduction to entrepreneurial strategy and new venture financing. Deliverables will include a technology feasibility analysis on a possible application in the student's scientific area. Offered as BIOL 493, CHEM 493, and PHYS 493.

CHEM 501. Special Topics in Inorganic Chemistry. 1 - 6 Unit.

(Credit as arranged.) Lectures on advanced topics in inorganic chemistry presented by staff or visiting lecturers. Course title, content, and credit change from year to year.

CHEM 502. Special Topics in Inorganic Chemistry. 1 - 6 Unit.

(Credit as arranged.) Lectures on advanced topics in inorganic chemistry presented by staff or visiting lecturers. Course title, content, and credit change from year to year.

CHEM 504. Special Topics in Organic Chemistry. 1 - 6 Unit.

(Credit as arranged.) Lectures on advanced topics in organic chemistry presented by staff or visiting lecturers. Course title, content, and credit change from year to year.

CHEM 506. Special Topics in Physical Chemistry. 1 - 6 Unit.

(Credit as arranged.) Lectures on advanced topics in physical chemistry presented by staff or visiting lecturers. Course title, content, and credit change from year to year.

CHEM 507. Special Readings in Chemistry. 1 - 6 Unit.

Detailed study of a special topic in chemistry under the guidance of a faculty member.

CHEM 508. Special Readings in Chemistry. 1 - 6 Unit.

Detailed study of a special topic in chemistry under the guidance of a faculty member.

CHEM 509. Special Topics in Analytical Chemistry. 1 - 6 Unit.


CHEM 601. Research. 1 - 18 Unit.

(Credit as arranged.) Special research in an area of chemistry under the guidance of a faculty member.

CHEM 605. Chemistry Colloquium Series. 1 Unit.

Course content provided by Thursday chemistry department colloquia (or Frontiers in Chemistry lectures). Discussion sessions review previous lectures and lay foundation for forthcoming lectures.

CHEM 651. Thesis M.S.. 1 - 18 Unit.

(Credit as arranged.)

CHEM 701. Dissertation Ph.D.. 1 - 18 Unit.

(Credit as arranged.) Prereq: Predoctoral research consent or advanced to Ph.D. candidacy milestone.