The mission of the Case Western Reserve University School of Medicine is to advance the health of humankind through the four interrelated components of Education, Research, Clinical Care and Public Service.
The School of Medicine provides two tracks leading to the MD degree: the longstanding School of Medicine program, also called the University track, and the Cleveland Clinic Lerner College of Medicine at Case Western Reserve University, also known as the College track, which first admitted students in 2004. The School boasts a longstanding Medical Scientist Training Program, or MSTP, and, through the School of Graduate Studies, programs resulting in PhD and MS degrees, as well as certificates in disciplines led by faculty in the School of Medicine.
As a research institution, the School of Medicine has a tradition of national leadership. The School of Medicine consistently ranks in the top tier of the nation’s medical schools for federal research funding from the National Institutes of Health, and is proud of its Clinical Translational Service Award in partnership with its affiliates. In fiscal year 2010, the School earned more than $340 million in grants from the NIH including grants through the affiliated Cleveland Clinic Lerner College of Medicine. Faculty and trainee research is routinely reported in the nation's top journals, leading to biomedical discoveries and improved health.
The School of Medicine engages the community in public service in many ways. The School of Medicine’s commitment links researchers and medical students to the community. The school’s faculty provide 90 percent of the indigent health care in Cuyahoga County and a majority of the care for indigent patients in Ohio. A major economic influence on the northern Ohio area, the School of Medicine and its affiliated hospitals are among the largest employers of personnel in the area and further stimulate the economy by providing concepts for technology transfer to the business sector. On the international level, the School of Medicine has a global health and diseases program focusing on AIDS, tuberculosis, malaria and other diseases that directly threaten world health.
The school is very proud of the contributions made by its educators and graduates but doesn’t rest on its laurels. The curriculum constantly responds to the latest findings in education and medicine and sets the pace for other schools with input from gifted and committed scholars.
At least eleven Nobel Prize holders have ties to the School of Medicine:
Two other distinguished alumni have served as U.S. surgeon general: Jesse Steinfeld, MD, a 1949 graduate, was surgeon general from 1969 to 1973, and David Satcher, MD, PhD, who graduated in 1970 and was surgeon general from 1998 to 2002.
Dr. Satcher also served as director of the Centers for Disease Control and Prevention from 1993 to 1998, and another medical school graduate, Julie Gerberding, MD, MPH, followed in his footsteps, in 2002 becoming the first woman to be named CDC director.
Since its founding in 1843, the Case Western Reserve University School of Medicine has been an innovator in medical education and a leader in pioneering research. Beginning as the Medical Department of Western Reserve College (and popularly known then as the Cleveland Medical College), the school moved into its first permanent home, in downtown Cleveland, in 1846. In 1915, a 20-acre site was secured for a medical center in University Circle, the current home of Case Western Reserve University, its School of Medicine, and two of the school’s affiliated hospitals, University Hospitals of Cleveland and the Louis Stokes Cleveland Department of Veterans Affairs Medical Center. University Circle also is home to many of the country’s outstanding cultural and educational institutions.
The school was one of the first medical schools in the country to employ instructors devoted to full-time teaching and research. Six of the first seven women to receive medical degrees from accredited American medical schools graduated from Western Reserve College (as it was called then) between 1850 and 1856.
Already a leading educational institution for more than a century, in 1952 the School of Medicine initiated the most advanced medical curriculum in the country, pioneering integrated education, a focus on organ systems and team teaching in the preclinical curriculum. This curriculum instituted a pass/fail grading system for the first two years of medical school to promote cooperation among students instead of competitiveness, introduced students to clinical work and patients almost as soon as they arrived on campus, and provided free, unscheduled time in an era when doing so seemed unthinkable. Many other medical schools followed suit, and these components remain at the core of the medical school’s curriculum today.
In 1924, the School of Medicine moved into the most modern and best-equipped preclinical science building in the country at that time. That building, donated by Cleveland industrialist Samuel Mather, remains an integral part of the medical school complex. It was named the Harland Goff Wood Building in 1993 in honor of the late chair and professor of biochemistry and former provost of the university.
In 1971, the Health Sciences Center was completed to house the university’s medical, dental and nursing schools, as well as the Health Center Library. In 1994, the health sciences complex was named for now-retired U.S. Congressman Louis Stokes. The proximity of these excellent research and educational centers to other prestigious university departments, including science, engineering and social sciences, stimulates uniquely creative interaction among researchers and educators.
Another giant leap in research capabilities came in the early 1990s, when the Richard F. Celeste Biomedical Research Building, named for the former Ohio governor, was opened. The $70 million building, attached to the Wood Building, added 154,000 square feet of research space and includes conference spaces, a lecture hall, public spaces and a cafeteria.
The School of Medicine was the first medical school to provide laptop computers to all its students. Today, students use their laptops to access the entire syllabus as well as numerous electronic resources deemed essential by faculty. Students have access to the WiFi network at the medical school and across campus. Technology is used to enhance, not replace, the faculty-student interaction that occurs in the classroom, the laboratory and small group discussions.
In 2002, the School of Medicine became only the third institution in history to receive the best review possible from the body that grants accreditation to U.S. and Canadian medical degree programs, the Liaison Committee on Medical Education. Also in 2002, the school built on its tradition of innovation in education when the university and the Cleveland Clinic entered into an agreement to form the Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, with the first class matriculating in 2004.
Recent boosts in research capabilities came with the spring 2003 dedication of a new, eight-floor addition to the School of Medicine’s Wood Building, which added more than 40,000 square feet to the medical school, primarily for research laboratories. Also as part of the project, 30,000 square feet of existing laboratory space in the Wood Building was renovated. And in the fall of 2003, the School of Medicine and University Hospitals of Cleveland dedicated the new, eight-floor Iris S. and Bert L. Wolstein Research Building, adding 320,000 square feet of space for up to 700 researchers.
Pamela B. Davis, MD, PhD
Dean, School of Medicine, and Senior Vice President for Medical Affairs
Carol L. Moss, MS
Vice Dean for External Affairs and VP for Medical Development
Sana Loue, PhD, JD
Vice Dean for Faculty Development and Diversity
Patricia Thomas, MD
Vice Dean for Medical Education
Mukesh Jain, MD
Vice Dean for Medical Sciences
Stanton Gerson, MD
Vice Dean for Oncology
Mark Chance, PhD
Vice Dean for Research
Michael W. Konstan, MD
Vice Dean for Translational Research
Lisa M. Mencini, CPA, MBA
Senior Associate Dean and Chief of Staff
Murray D. Altose, MD
Senior Associate Dean for Louis Stokes Veterans Affairs Medical Center
Alfred Connors, Jr., MD
Senior Associate Dean for the MetroHealth System
C. Kent Smith, MD
Senior Associate Dean for Students and Assistant Dean for Student Societies
James Young MD
Executive Dean for Cleveland Clinic Lerner College of Medicine
Lina Mehta, MD
Associate Dean for Admissions
Jeffrey L. Ponsky, MD
Associate Dean for Alumni Affairs
Alan Hull, MD, PhD
Associate Dean for Curricular Affairs for Cleveland Clinic Lerner College of Medicine
Amy Wilson-Delfosse, PhD
Associate Dean for Curriculum
Robert Daroff, MD
Associate Dean for Development
Gene H. Barnett, MD
Associate Dean for Faculty Affairs for Cleveland Clinic Lerner College of Medicine
Daniel E. Anker, PhD, JD
Associate Dean for Faculty Affairs and Human Resources
Paul N. MacDonald, PhD
Associate Dean for Graduate Education
Susan Nedorost, MD
Associate Dean for Graduate Medical Education
Associate Dean of Marketing and Communications
Fabio Cominelli, MD
Associate Dean for Program Development
Jill Stanley, MBA
Associate Dean for Space and Facilities Planning
Kathleen N. Franco, MD
Associate Dean Student Affairs & Admissions for Cleveland Clinic Lerner College of Medicine
Robert L. Haynie, MD, PhD
Associate Dean for Student Affairs and Assistant Dean for Student Societies
Assistant Dean for Administrative Operations
Henry Ng, MD
Assistant Dean for Admissions
Christine D. Schomisch Moravec, PhD
Assistant Dean for the Basic Science Curriculum, CCLCM
Robert Petersen, PhD
Assistant Dean for Basic Science Education
Susan Padrino, MD
Assistant Dean for Clinical Sciences
J. Harry Isaacson, MD
Assistant Dean for Clinical Education for Cleveland Clinic Lerner College of Medicine
Neil Mehta, MD
Assistant Dean for Education Informatics and Technology, CCLCM
Nicole M. Deming, JD
Assistant Dean for Faculty Affairs and Human Resources
Nicole Addington, CPA
Assistant Dean for Finance and Planning
Assistant Dean for Grants and Contracts
Mamta Singh, MD
Assistant Dean for Health Systems Science
David M. Pilasky, MHA, MCIS
Assistant Dean for Information Technology
Colleen Croniger, PhD
Assistant Dean for Medical Student Research
Assistant Dean for Oncology
Joan M. Schenkel, MS
Assistant Dean for Research Administration
Linda M. Graham, MD
Assistant Dean for Research Education for Cleveland Clinic Lerner College of Medicine
Lynda Montgomery, MD
Assistant Dean for Student Affairs
Steven Ricanati, MD
Assistant Dean for Student Affairs
Margaret Larkins-Pettigrew, MD
Assistant Dean for Student Affairs
Marjorie Greenfield, MD
Assistant Dean for Student Affairs
Siu Yan Ng Scott, LSW
University Hospitals serves the needs of patients through an integrated network of hospitals, outpatient centers and primary care physicians. At the core of the health system is University Hospitals Case Medical Center. The primary affiliate of Case Western Reserve University School of Medicine, University Hospitals Case Medical Center is home to some of the most prestigious clinical centers of excellence in the nation and the world, including cancer, pediatrics, women's health, orthopedics and spine, radiology and radiation oncology, neurosurgery and neuroscience, cardiology and cardiovascular surgery, organ transplantation and human genetics. Its main campus includes the internationally celebrated UH Rainbow Babies & Children's Hospital, ranked among the top children’s hospitals in the nation; UH MacDonald Women's Hospital, Ohio's only hospital for women; and UH Seidman Cancer Center, part of the NCI-designated Case Comprehensive Cancer Center. Go here for more information.
In 2002, the university and Cleveland Clinic entered into a landmark agreement to form the Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, with the first students matriculating in 2004. The "College Track" is a program within the Case Western Reserve University School of Medicine. The Cleveland Clinic serves as an outstanding teaching site for all medical students in the School of Medicine, in addition to being the site for pre-clerkship education in the College Track.
Cleveland Clinic was founded in 1921 by four Case Western Reserve faculty members, three of whom are counted among the alumni of the Case School of Medicine. Cleveland Clinic’s main campus, where much of the activity associated with the program will occur, is located on 180 acres adjacent to the Case Western Reserve campus.
Occupying 50 buildings, the main campus includes a hospital, an outpatient clinic, a children’s hospital, heart and vascular institute, cancer institute, eye institute, research institute and supporting labs and facilities. To better serve the Cleveland suburbs with primary care services, Cleveland Clinic operates 16 family health centers, eight regional hospitals and medical offices throughout Northeast Ohio, staffed with Cleveland Clinic primary care physicians, as well as many medical and surgical specialists. State-of-the-art imaging services are available, and several locations contain pharmacies and outpatient surgery centers that provide same-day surgical services close to home. In 2011, the clinic recorded more than 4.2 million outpatient visits throughout the health system and 155,000 hospital admissions. Among them were patients from all 50 states and more than 100 countries. More than 2,800 full-time physicians and scientists and 11,000 nurses represent 120 medical specialties and subspecialties. Cleveland Clinic is consistently named as one of the nation's top hospitals by U.S. News & World Report, and our heart and heart surgery program has been ranked No. 1 by U.S. News since 1995. Go here for more information.
The MetroHealth System is one of the largest, most comprehensive health care providers in Northeast Ohio, caring for people in and around Greater Cleveland for more than 170 years. This academic health care system is committed to the communities it serves by saving lives, restoring health, promoting wellness, and providing outstanding, lifelong care that is accessible to all.
Affiliated with Case Western Reserve University School of Medicine since 1914, MetroHealth is a center for medical research and education, with all active staff physicians holding CWRU faculty appointments. More than 400 primary care and specialty care physicians practice within The MetroHealth System. At the core of the MetroHealth system, is the MetroHealth Medical Center. The system’s main health care provider, research facility and teaching hospital is also home to the region’s only Level 1 trauma and burn center. However, The MetroHealth System also serves Greater Cleveland with more than a dozen urban and suburban primary and specialty healthcare centers in Cleveland, Strongsville, Westlake, Lakewood, Pepper Pike and Beachwood.
MetroHealth has received many accolades for its high level of care and the innovation of its physicians. Surgeons at MetroHealth are pioneering new techniques in minimally-invasive surgery for faster recoveries, while its primary care physicians are developing cutting-edge ways to manage common and chronic diseases through the use of electronic medical records and a patient-centered medical home model called Partners in Care. Its maternal-fetal medicine specialists are successfully managing the riskiest of pregnancies and saving the tiniest of lives. In addition, MetroHealth is nationally recognized by the American Heart Association for cardiac and stroke care and the cancer center has earned outstanding achievement awards for the treatment of cancer patients. Every year, MetroHealth provides care to more than 28,000 inpatients and delivers approximately 3,000 newborns. More than 790,000 visits are recorded each year in the medical center's outpatient centers, and patient visits to the emergency department exceed 99,000. To learn more about MetroHealth and its locations and services, go here.
The Louis Stokes Cleveland Department of Veterans Affairs Medical Center (VAMC) is a major teaching hospital of the School of Medicine and is an important site for the education of medical students. The Cleveland VAMC also supports more than 100 residency and fellowship training positions in medicine, surgery, and psychiatry and their subspecialties. Most VAMC physicians hold faculty appointments within the School of Medicine. The affiliation is overseen by the Deans Committee, consisting of the dean, department chairpersons from the School of Medicine, and key VAMC officials.
The Cleveland VAMC is a part of the VA Healthcare System of Ohio, linking VA health care facilities in Ohio in an integrated service network. Inpatient care is provided at the Wade Park location and includes medicine, surgery, psychiatry, spinal cord injury, neurology and rehabilitation medicine as well as a nursing home and a domiciliary. Outpatient care is delivered in primary and specialty care clinics located at Wade Park, Akron, Canton, Cleveland, East Liverpool, Lorain, Mansfield, New Philadelphia, Painesville, Ravenna, Sandusky, Warren and Youngstown. The medical center serves more than 100,000 individual veterans annually through approximately 11,600 hospital admissions and 1,884,000 outpatient visits.
An active research program includes activities funded through the Department of Veterans Affairs and other governmental and private funding sources. Total funding of approximately $21.5 million annually (from all sources) supports more than 50 principal investigators in a broad range of research endeavors. For more information, go here.
Ronald J. Triolo, PhD, Executive Director
Gilles Pinault, MD, Medical Director
The Advanced Platform Technology (APT) Research Center of Excellence is a multi-institutional center composed of investigators from Case Western Reserve University and the Louis Stokes Cleveland Department of Veterans Affairs. Building on the 25+ year history of rehabilitation research in northeast Ohio, the Center was created in 2005 with a $5.0 million award from the Veterans Health Administration [VHA] Rehabilitation Research and Development Service as a national VA Research Center of Excellence. This commitment was subsequently renewed in 2010 for a second 5-year term with an additional award of $5.0 million. An additional $6 million award in 2010 from the State of Ohio’s Department of Development further validated the Center’s ability to achieve its primary mission to serve the clinical needs of veterans with motor, sensory and cognitive deficits and limb loss. The total value of the APT-related research portfolio is presently $45 million.
The APT Center is providing leadership to create and deliver innovative devices based on cutting-edge microelectronics, materials and MEMS fabrication and is a catalyst for the discovery and development of new technologies and techniques that can be employed in the rehabilitation process to provide independence for veterans and other individuals with disabilities. These techniques include basic and clinical research programs and the development and administration of new device-based therapies to patients within the emphasis areas of neural interfaces, prosthetics and orthotics, health monitoring & maintenance and enabling technologies. The Center provides affiliated investigators seed funding, administrative support (grants preparation and management, regulatory and statistical support), professional engineering & prototyping and an established quality system for the documentation and control of device design and production. Leveraging its investigators’ exceptional track records in a variety of disciplines, the Center is promoting the translation of its research into clinical and commercial applications. Current clinical applications being investigated include intelligent braces, respiratory support, sensation and control of a prosthetic hand, urinary incontinence, behavioral recovery after traumatic brain injury and, monitoring brain activity.
Stanton L. Gerson, MD, Director, Case Comprehensive Cancer Center
Anne M. Duli, MPA, Associate Director, Research Administration and Finance
The Case Comprehensive Cancer Center (Case CCC) is one of only 41 National Cancer Institute-designated Comprehensive Cancer Centers in the country. The Case CCC integrates the cancer research activities of the largest medical collaborative in Ohio, Case Western Reserve University (CWRU), University Hospitals Case Medical Center and Cleveland Clinic - under a single leadership structure. Our researchers dedicate themselves to improving cancer outcomes through basic studies into signaling pathways giving rise to cancer and its generic and epigenetic causes, pursuing novel therapeutic targets, and analyzing lifestyle interventions to prevent cancer and detect it earlier.
The Case CCC has over 360 collaborating scientists and physicians who have successfully competed for over $119 million in annual funding. These investigators are organized into eight interdisciplinary scientific programs and have access to 15 Scientific Core Facilities. A unified clinical research effort consisting of 12 multidisciplinary clinical disease teams develop and prioritize clinical trials among the partner institutions.
Located in Cleveland, Ohio, the Case CCC serves a population with higher than average cancer rates. Research programs extend to CWRU affiliates MetroHealth Medical Center (the region’s county hospital) and Louis Stokes Veterans Affairs Hospital and to 13 community medical centers operated by University Hospitals and Cleveland Clinic.
As a consortium cancer center, Case CCC has become a powerful example of the potential generated by complementary institutions coming together for the benefit of research and discovery, patient treatments and community impact. Through its partners, Cancer Center programs extend throughout Northeast Ohio to offer residents access to cancer care through participation in community outreach, cancer prevention, cancer survivorship initiatives and a robust clinical trials operational effort coordinated across academic medical centers and community sites.
Mukesh K. Jain, MD, Director, Case Cardiovascular Research Institute
Daniel I. Simon, MD, Director, University Hospitals Harrington-McLaughlin Heart & Vascular Institute Director, Case Cardiovascular Center
The Case Cardiovascular Center was established in 2006 with the central mission to develop premier clinical, research, and education programs in heart and vascular disease. The structure of the Center includes clinical (University Hospitals Harrington-McLaughlin Heart & Vascular Institute—UH-HMHVI) and research (Case Cardiovascular Research Institute—CVRI) arms.
The UH-HMHVI is a multi-disciplinary team of nearly 60 full-time faculty members dedicated to (a) the prevention, diagnosis, and treatment of heart and vascular disease to both local and regional patient populations in Northeast Ohio, (b) the education and training of medical students, residents and fellows, and (c) the development of breakthrough medical advancements and practices to deliver superior clinical outcomes. These clinical services range from primary to quaternary levels of expertise and are provided at all the health are facilities within the University Hospitals healthcare system. The clinical programs are organized into 11 program centers that comprise the Institute.
The research activities of the CCC are focused on the development of premier research programs that span the full spectrum of activities from basic bench-side research to translational research (“first-in-man”) and clinical trials. The CVRI is focused on basic and translational studies. The Research & Innovation Center (RIC) of the UH-HMHVI is dedicated to innovative clinical trials and applied technology. The major areas of research focus in the CVRI include cardiovascular biology, mechanisms of gene regulation, innate immunity & inflammation, and stem cell & regenerative medicine. Investigators in the CVRI have full access to two laboratories for in vivo research in small and large animals. The RIC oversees all clinical research activities within cardiovascular medicine and surgery and is supported by a lead administrator along with nurse coordinators and staff to facilitate patient enrollment as well as regulatory/grant activities. Active areas of clinical research include interventional cardiology, vascular medicine, heart failure, electrophysiology, preventive cardiology& rehabilitative medicine, and cardiovascular imaging.
James Basilion, PhD, Co-Director
Robert Gilkeson, MD, Co-Director
Chris Flask, PhD, Scientific Director
The CCIR is a joint venture between Case Western Reserve University School of Medicine and University Hospitals of Cleveland. The CCIR through its 40 faculty and state-of-the-art clinical and preclinical imaging capabilities promotes interdisciplinary and translational imaging research. The CCIR also serves as a shared resource for CWRU’s Cystic Fibrosis Center, the Case Comprehensive Cancer Center, the Center for Stem Cell and Regenerative Medicine, and the Clinical and Translational Science Collaborative (CTSC). As the imaging research program at CWRU continues to grow, we strive to make the CCIR imaging capabilities available to the broader research community. This overriding goal has led to a strong collaborative relationship between the CCIR imaging faculty and basic researchers in many disciplines.
Preclinical imaging facilities includes four high resolution MRI scanners, a microPET/CT scanner, a microSPECT/CT imaging system, and three bioluminescence/fluorescence systems. In addition,magnetic relaxomtery scanners for high throughput screening of developmental MRI contrast agents, and recent addition of a cryofluorescence imaging system to obtain high resolution, 3D optical imaging capabilities enhance our technologies. CCIR staff provides quantitative image analysis as needed for specific applications. The CCIR clinical imaging research facilities offer a full range of imaging support. The facility includes 4 MRI scanners and one human PET/CT for clinical research studies. The CCIR has also recently completed a $1.2M construction project to create a new radiopharmaceutical facility. Together with our existing cyclotron and radioisotope delivery system, our imaging center now has the capacity to conduct a variety of molecular PET imaging studies from preclinical animal studies all the way to routine clinical studies.
Jonathan Karn, PhD, Director
Michael Lederman, MD, Associate Director
Since its founding in 1994, the Case Western Reserve University/University Hospitals Center for Aids Research (Case CFAR) has been a center of excellence for both clinical and basic science AIDS research. Investigators participating in the Case CFAR draw on resources from the Case Western Reserve University School of Medicine, University Hospitals Case Medical Center, MetroHealth Medical Center and the Cleveland Clinic Foundation and the Joint Clinical Research Center in Kampala Uganda. As the only NIH-funded CFAR in the Midwestern United States, the CFAR plays an important role in ensuring that cutting-edge AIDS research and well received community outreach is supported in our region of the country. Major strengths in the Case CFAR include international research, especially with respect to research in tuberculosis and HIV malignancy, microbicides, pathogenesis, virology, clinical trials, and training, at the national and international levels. As the first CFAR to make a major investment in international research, we have been able to expand a highly productive and long-standing scientific relationship with Makerere University, Kampala.
The Case CFAR shares and supports the mission of the National CFAR program to support a multi-disciplinary environment that promotes basic, clinical, epidemiologic, behavioral, and translational research in the prevention, detection, and treatment of HIV infection and AIDS. The Case CFAR provides: Leadership and strategic planning that promotes and supports outstanding HIV/AIDS research at our participating institutions, laboratory cores with expertise, state-of-the-art instrumentation and technologies; pilot grant awards and mentoring to develop junior faculty interested in HIV; educational and training efforts which encompass the whole range of contemporary HIV/AIDS research; community outreach programs, and the promotion of and participation in collaborative research efforts within the national CFAR network and in Uganda.
Leona Cuttler, MD, Director
Ann Nevar, MPA, Supervisor
Established in 2007, the Center for Child Health and Policy at Rainbow focuses on major health policy issues that are central to the well-being of children and youth. The Center recognizes that health policy forms a framework for all health care delivery, and that health policy is therefore essential to improving children’s health. In this way, the Center focuses on the nexus between policy and practice of pediatric medicine.
The Center fills the need to amalgamate expertise in pediatric medicine and research with expertise in health policy. Operating as a think tank, the Center brings together experts in child health, health finance, law and policy to perform policy analyses, consultations, research, educational programming, and community outreach to advance child health through policy. Work is focused on several areas including: Maternal/Fetal/Newborn Health; Chronic Illness; Quality; and Care Delivery Systems. The Center is the only program devoted to child health policy in Cleveland and one of few nationwide.
To date, the Center has accrued many products and achievements including: Ohio Health Policy Researcher of the Year in 2006; Ohio Health Policy Researcher of the Year for Independent Research in 2009; programs designated Centers of Excellence; multiple white papers, reports, and peer-reviewed publications; grants and awards from the National Institutes of Health, The Centers for Disease Control and Prevention, the Ohio Department of Health, the Ohio Department of Job and Family Services, and numerous foundations; and invited/elected memberships in state and national policy committees.
James Spilsbury, PhD, Academic Development Core Director
Nathan Morris, PhD, Statistical Sciences Core Director
The Center for Clinical Investigation (CCI) was founded in 2007 and is part of Case Western Reserve University School of Medicine’s Division of General Medical Sciences. The CCI serves as the academic home of Cleveland’s Clinical & Translational Science Collaborative, a partnership of 4 local institutions (Case Western Reserve University, the Cleveland Clinic Foundation, the MetroHealth System, and University Hospitals) and member of a national consortium of approximately 66 institutions funded by the National Institutes of Health to increase the efficiency and speed of clinical and translational research across the country.
The CCI’s mission is to enhance clinical and translational research efforts across the Cleveland area by: (1) spurring advances in knowledge of risk factors, outcomes and treatment effectiveness in the population; (2) facilitating the transfer of scientific advances to the community; and (3) developing a new generation of clinical researchers equipped with the skills needed to efficiently design, implement and interpret novel studies that address important public health questions. To accomplish its mission, the CCI provides computer systems and applications support for basic science and clinical research activities and works closely with basic science and clinical investigators in the CWRU Schools of Medicine, Nursing, and Dental Medicine, as well as the University Hospitals Case Medical Center, Cleveland Clinic, and MetroHealth System . The CCI has supported hundreds of clinical research and epidemiology projects, including local and national multicenter, longitudinal studies. The CCI has two cores that provide research support to all investigators: the Academic Development Core and Statistical Sciences Core.
The Academic Development Core manages the newly created PhD Program in Clinical Translational Science, the Master’s Degree Program in Clinical Research (Clinical Research Scholars Program - see "Clinical Research MS" tab above), and the Graduate Certificate Program in Clinical Research. The Academic Development Core also delivers seminars and short courses in clinical research and works to coordinate educational activities in interdisciplinary clinical research across the CTSC’s institutional members. The programs target investigators and other key members of the research team, including data managers and study coordinators. Training efforts in research design, research data management, statistical sciences, statistical software, and scientific communication are emphasized.
The Statistical Sciences Core provides data management and statistical support on study design and data analysis. Members who provide data management consist of skilled data managers and programmers who consult and collaborate with investigators on data collection instrument development and coding, database development and administration, data cleaning and quality assurance, statistical programming, and dataset preparation. Members providing statistical support collaborate and consult with clinical investigators on proposal development, study design, study monitoring, and data analysis. "The Statistical Sciences Core currently consists of 1 PhD biostatistician and 1 MS biostatistician. Statistical software packages that are supported by the CCI Statistical Sciences Core include SAS, SPSS, R/S-Plus, NCSS PASS and Minitab. In addition, the Statistical Science core serves as a gateway for connecting investigators with the broad expertise available through the Biostatistics faculty in the department of Epidemiology and Biostatistics."
James W. Kazura, MD, Director
The Center for Global Health and Diseases links the numerous international health resources of the University, its affiliated institutions, and the northern Ohio community in transdisciplinary programs of research and education related to global health. The scope of the Center's activities also includes education and service as these are related to molecular, clinical and population studies of human health and disease.
The Center is currently a national leader in National Institutes of Health-supported studies of the major infectious diseases of developing countries. Cutting-edge approaches are implemented in order to examine the molecular, genetic and immunologic basis of susceptibility to infectious diseases of public health significance - malaria, river blindness, lymphatic filariasis, schistosomiasis, HIV and other viral diseases such as Rift Valley fever. Clinical research in endemic countries is concerned with testing and implementing cost-effective public health interventions that are aimed at the control of malaria and Neglected Tropical Diseases (worm infections of children, elimination of lymphatic filariasis). The Center has ongoing research and educational collaborations with academic and governmental institutions in Papua New Guinea, Brazil, Kenya, Uganda, and several other countries in Sub-Saharan Africa. Educational programs sponsored by the Center include electives in international health, population biology, and genetics of infectious diseases (available to undergraduate, graduate and professional school students), a weekly World Health Interest Group (WHIG) seminar series, overseas rotations for graduate and professional school students, and training programs at the university and abroad for scholars from developing countries (with support from the Fogarty International Center at NIH).
A certificate in Global Health is available (see Certificates).
Randall D. Cebul, MD, Director
The mission of the Center for Health Care Research & Policy is to: 1) improve the health of the public by conducting research that improves access to health care, increases the quality and value of health care services, and informs health policy and practice; and 2) lead education and training programs that promote these goals. Formally established in 1994, the Center’s mission is carried out by a cross-disciplinary faculty who both lead and collaborate with other scholars in Northeast Ohio and beyond. A core faculty of 17 is extended by affiliated Senior Scholars throughout the university, assisted by an able staff and over 30 grant-supported research associates. The Center’s home at MetroHealth’s Rammelkamp Research and Education Building is an outstanding venue for collaborative research, mentoring of students and junior faculty, and cross-disciplinary seminars.
The Center’s research and training focuses in programmatic areas that reflect national health care priorities as well as high impact problems in adults. Center Programs pertain to chronic conditions, especially stroke, obesity and diabetes, and kidney disease. Programs are supported by methods units, including biostatistics and evaluation, health care decision making, and health economics and health policy. Research using clinical informatics capitalizes on growing institutional capacities in electronic medical records (EMR) and clinical decision support. Center faculty view Northeast Ohio as a laboratory for research, recognizing the national relevance of regional challenges and opportunities. For over four years, the Center has served as the administrative home for Better Health Greater Cleveland, an EMR-catalyzed initiative to measure, publicly report, and improve health outcomes for the region’s residents with chronic medical problems. Center faculty also assume leadership roles in federally-supported degree programs in Health Services Research and Clinical Investigation and teach in the core curriculum of the School of Medicine.
Patricia A. Thomas, MD, FACP, Director
Klara Papp, PhD, Director, CAML
The Center for Medical Education, established in 2010, provides an organizational home for teaching and learning programs in the School of Medicine and a supportive environment for those who want to develop special skills in medical education.
The Center also sponsors faculty appointments, both full- and part-time, for faculty whose roles are predominantly focused on teaching medical students and physician assistant students. These include community clinicians who welcome medical students into their clinics and practices.
The Center for the Advancement of Medical Learning (“CAML”) operates its programs under the auspices of the CMEd. CAML supports and promotes the development of teaching and lifelong-learning skills among students, faculty, staff, residents, and alumni. CAML pursues research into educational innovations to advance our knowledge of medical learning and teaching. The Center offers workshops to faculty locally, regionally, and nationally to enhance faculty teaching, research and evaluation skills.
Biomedical Research Building, Ninth Floor
Mark R. Chance, PhD, Director
The Case Center for Proteomics and Bioinformatics was created, in part, to strengthen Cleveland's presence in modern proteomics and bioinformatics research to make the region a leader in the field. The vision for the Center has been shaped over the past several years by the leadership of the Center.s Director, Mark Chance, Ph.D, with over $80 million in grants awarded to the Center and its collaborators since its inception in February 2006. One of the primary goals of the CPB is to develop an infrastructure of sophisticated equipment that facilitates and maximizes shared equipment usage, as well as to offer a wide array of proteomics and bioinformatics services including mass spectrometry, protein expression/interactions, systems biology, and biostatistical analyses.
The CPB has expanded its vision to include education of graduate students in systems biology and bioinformatics. The Center for Proteomics and Bioinformatics developed a graduate program in Systems Biology and Bioinformatics in collaboration with Schools and Departments across the campus. For more information regarding the SYBB graduate program please see "Systems/Bioinformatics" tab above. You may also visit http://bioinformatics.case.edu/.
Proteomics entails the in depth structural analysis of individual proteins in human and animal cells. In studying proteins and their changes, bioinformatics enables researchers to take an integrated -omics approach for discovering networks involved in human disease. The School of Medicine has established the Center for Proteomics and Bioinformatics to perform research to better understand the genetic and environmental bases of disease as well as provide new technologies to diagnose diseases such as cancer, heart disease, and diabetes.
New technologies in mass spectrometry are also allowing protein expression, localization, structure, post-translational modifications, and interactions to be studied in increasing detail and on a genome wide scale. The Center is also developing and applying state-of-the-art-structural proteomics technologies to understand the function and interactions of macromolecular complexes.
The CPB has three divisions: Proteomics and Genomics, Bioinformatics, and Macromolecular Structure.
Proteomics and Genomics Division
The mission of the Division of Proteomics and Genomics is to support research in protein and gene expression analysis, protein and gene modifications, and protein interactions in a wide variety of biological contexts. The division also develops new tools in Proteomics and Genomics research. This includes multiple Proteomics Cores to support these activities.
The mission of the Division of Bioinformatics is to support interdisciplinary research and training in many areas of bioinformatics including analysis of DNA and protein sequences, protein interaction networks, linkage and association studies for simple and complex traits, and gene and protein expression profiles. This includes a Bioinformatics Core that provides research support for these activities.
Macromolecular Structure Division
The mission of the Division of Macromolecular Structure is to support interdisciplinary research in new methods of structure determination, the combination of computational and experimental structural biology approaches, and developing and maintaining infrastructure for macromolecular structure determination. The Division will work closely and coordinate their activities with faculty and Departments in the University who use structural information to understand function as well as other Centers that provide leadership in Structural Biology and Biophysics.
The CPB also offers a wide range of seminars, workshops, and possibilities for individual training. These activities are posted on the CPB Web site. For a list of services and to explore opportunities to collaborate, please visit the Web site: http://proteomics.case.edu/index.html or e-mail: email@example.com.
Kimberly Bell, PhD; John A. Hadden Jr. Assistant Professor of Psychoanalytic Child Development
The Center for Psychoanalytic Child Development was established in 2001 in memorial to John A. Hadden Jr., past President of the Board of Trustees of the Cleveland Center for Research in Child Development and of the Hanna Perkins School. The mission of the center is to advance the science of psychoanalytic child development at the School of Medicine.
The Center offers medical students and residents who are interested in working with children the opportunity for observational learning in the Hanna Perkins school. In addition, didactic courses, case conferences and supervision are available to deepen students’ understanding of the relationship between physical and psychological development in the first 5 years of life.
Jeffery M. Coller, PhD, Director
The Center for RNA Molecular Biology is a free standing academic unit in the basic sciences within the School of Medicine at Case Western Reserve University. The RNA Center was established in the mid-nineties as a core entity in recognition of the strong cadre of research laboratories devoted to studying post-transcriptional mechanisms of gene expression focusing on various aspects of RNA Biology. The RNA Center is currently composed of 8 primary faculty members and 10 secondary members.
The RNA Center contains the largest concentration of RNA molecular biologists in the nation. Collectively, the faculty of the RNA Center cover nearly every aspect of RNA research. Current research in the Center focuses on several of these problems ranging from extremely basic questions such as the mechanism of RNA catalysis and how proteins interact with RNA to the roles of RNA processing in disease. Specific research interests include splicing and its regulation, RNA editing, tRNA maturation, mechanisms of translation regulation, RNA degradation, RNA trafficking, RNA interference and regulation of gene expression by microRNAs and non-coding RNAs.
Collectively, the RNA Center provides a valuable resource for collaborative efforts within the University and its affiliated institutions the Cleveland Clinic Foundation, and University Hospitals System. In addition, the official journal of the RNA Society “RNA” was founded and continues to be housed in the RNA Center. The members of the RNA Center have an excellent funding record and the research performed is regularly published in highly visible journals such as Science, Nature, Molecular Cell, NSMB, Molecular Cell, etc. In addition, a comprehensive laboratory manual on RNA technology has been co-authored by the Center’s former director, Dr. Nilsen.
Nathan A. Berger, MD, Director
Recognizing that the successful futures of Case Western Reserve University, the City of Cleveland, and Cuyahoga County are integrally related, the Center for Science, Health and Society (CSHS) was created in 2002 to focus the efforts of the University and the community in a significant new collaboration to impact the areas of health and healthcare delivery systems through community outreach, education, and health policy. The Center, based in the School of Medicine, with university wide associations is engaging the many strengths of the University and the community to improve the health of the community.
The Center has engaged the community at the level of the individual and the neighborhood, in public and private schools, at civic and faith-based organizations, and at the level of governmental agencies and community leadership to identify community problems, perceptions, assets and resources; advise the community of faculty skills, assets and expertise; and, catalyze that community service based scholarship that benefits community interests and promotes mutual enhancement. The Center coordinates the Scientific Enrichment Opportunity outreach program that brings Cleveland high school students on to the medical school campus in the summer to work along with our distinguished faculty in their research labs, to introduce and stimulate the students and help prepare them to enter careers in the health carieer professions and biomedical workforce. The Center also coordinates the Mini Medical School Program presented every Spring and Fall to educate the community in the latest developments in healthcare, particularly those developed at CWRU. The overall goal of these programs is to educate and empower the community to become better consumers of healthcare and more informed and stronger advocates for healthcare policy and legislation in their own interests.
John R. Sedor, MD, co-director
Donald E. Hricik, MD, co-director
Walter Boron, MD, PhD, co-director
Chronic Kidney Disease (CKD) is a growing public health problem in the United States. Ten percent of US adults—more than 20 million Americans—have CKD. The prevalence of CKD increased by 30% in the decade between 1994–2004 due largely to an increased prevalence of diabetes, hypertension, and obesity. CKD generally progresses over time, and can cause cardiovascular disease, anemia, bone disease, fluid overload, and eventually end-stage kidney disease (ESKD). Patients with ESRD need renal replacement therapy, either from dialysis or a kidney transplant, to live. The risk of death for patients receiving dialysis is nearly eight times higher than the non-ESRD population, leading to a 20% annual probability of death. Kidney disease disproportionately affects minorities and vulnerable populations. Kidney disease treatment is expensive and uniquely tied to federal expenditures through the Medicare entitlement program. As of 2013, approximately 616,000 patients are receiving dialysis or have had a kidney transplant, costing the federal government nearly $35 billion annually. The combined annual cost to Medicare for treating all health conditions faced by patients with CKD and ESRD has reached $80 billion, nearly 25% of the Medicare’s budget.
The Center’s mission is to accelerate discovery and its translation for treatment and cure of kidney diseases in an interdisciplinary environment within the rich, research environment of the CWRU School of Medicine. The faculty is an accomplished and highly interactive group of investigators, based in the adult or pediatric Divisions of Nephrology in CWRU-affiliated hospitals and the Department of Physiology and other clinical and basic departments. Research interests of the faculty include glomerular development and disease, epithelial cell biology and ion transport, tubular physiology, genetic epidemiology, health services research, renal transplantation, health disparities research and clinical trials. Research faculty apply cellular, molecular biological, genetic, genomic and epidemiological methods to in vitro models, animal models and/or patients. Many projects by Center investigators use health data, culled from robust electronic health records, and biological samples from patients with kidney diseases in order to generate novel hypotheses, which can then tested with animal models and cell lines. Training opportunities are available for undergraduate, pre- and post-doctoral students.
David M. Katz, PhD, Director
The goals of the Center for Translational Neuroscience are to develop scientific interactions that promote understanding of the pathology of neurological diseases and to develop novel therapeutic strategies for the treatment of those diseases. The Center pursues these goals through Translational Interest Group meetings and events, and through the Neurological Institute, in the University Hospitals Case Medical Center, where clinicians and investigators have a direct conduit between research and developing treatments.
Robert F. Kirsch, PhD, Executive Director
Robert Ruff, MD, PhD, Medical Director
The Cleveland Functional Electrical Stimulation (FES) Center is a consortium of three nationally recognized institutions: Department of Veterans Affairs, MetroHealth Medical Center and Case Western Reserve University. Through the support of these partners, the Cleveland FES Center is able to provide a continuum of advancement. Created in 1991 with a grant from the Department of Veterans Affairs, the FES Center currently has research funding at the federal, state and local levels and additional industry and foundation funding in excess of $17M in order to achieve its mission.
The Center focuses on the application of electrical currents to either generate or suppress activity in the nervous system. This technique is known as functional electrical stimulation (FES). FES can produce and control the movement of otherwise paralyzed limbs for standing and hand grasp, activate visceral bodily functions such as bladder control or respiration, create perceptions such as skin sensibility, arrest undesired activity such as pain or spasm, and facilitate natural recovery and accelerate motor relearning.
Founded to introduce FES into clinical practice, the Center provides innovative options for restoring neurological health and function by developing advanced technologies and integrating them into clinical care.
Jonathan S. Stamler, MD, Director
The Institute for Transformative Molecular Medicine (ITMM), which operates under the combined aegis of Case Western Reserve University and University Hospitals, is composed of physician-scientists and basic discovery researchers who work to acquire fundamental scientific knowledge within the field of molecular medicine. Founded in 2010, the ITMM provides physician-scientists with the opportunity for professional advancement based on their contributions to life sciences, protected from demanding clinical schedules or administrative responsibilities. The mission of the ITMM is to foster the unrestricted pursuit of new knowledge that can be cultivated as the basis for therapeutic innovation, and to inspire new generations of physician-scientists.
The operation of the ITMM is based on a new model that unites academic medical centers, physician- and discovery-scientists and commercial partners to maximize the conversion of basic science discoveries into novel, high-value therapeutics. Thus, the ITMM facilitates connectivity between medical disciplines and the basic research community in order to catalyze fundamental discovery and its transformation into therapies that benefit humankind. Creativity and innovation are highly valued in the culture fostered by the ITMM. Expertise in interdisciplinary science is prioritized, including signal transduction, receptor biology, regenerative medicine, RNA biology and chemical biology, in the pursuit of cutting-edge advances that can impact human disease.
Mark I. Aeder, MD, Medical Director
The Mt. Sinai Skills and Simulations Center (MSSSC) was initially conceived in response to common concerns over the nationwide increased incidence of medical errors, the rising costs of health care, and the need for improved patient-caregiver communication. Since its founding in 2006, the MSSSC continues to work with an ever expanding list of health care partners to become an integral resource for the education of health care students and professionals in the Northeastern Ohio region and throughout Ohio. The MSSSC and The Institute for Surgical Innovation (ISI) combine to form the Case Western Reserve University Center for Skills and Simulation (CWRU-CSS).
Simulation develops confident practitioners who can significantly contribute to the goal of improved patient outcomes. By providing a variety of simulation tools, such as life-like computerized manikins and standardized professionals performing within carefully crafted scenarios, we can replicate the complex environment of the clinical setting. Participation in these specially designed scenarios allows learners to practice the critical skills needed to provide safe, quality care to patients, including communication, technique development, decision making and data analysis. These models have allowed us to have ongoing research projects in education development and intervention and advanced our partnership for the development of new techniques and materials.
The MSSSC has all the tools available for simulation training, including Standardized patients – individuals trained to portray situations or conditions; Task trainers – devices uses to teach individual techniques; High fidelity trainers – manikins with programming capabilities; Virtual reality – real life interactive trainers for surgery, cardiology and other disciplines; Second life – avatar interactions in a computerized world; and Hybrid combinations of the above.
The CWRU-CSS is an American College of Surgeons Level 1 Accredited Educational Institute, During the past five years, the Center has provided educational opportunities and course for learners at all levels from high school students, medical, dental and nursing students at Case Western Reserve University and The Lerner College of Medicine, residents and fellows from training programs at University Hospitals Case Medical Center, The Cleveland Clinic and MetroHealth Medical Center, graduate education for practicing physicians and surgeons, nursing and other health care providers at all levels, first responders including EMS and fire/rescue, flight nurse training and military reserve medical units.
Dorr G. Dearborn, MD, PhD, Director
The Swetland Center for Environmental Health is an environmental clinical center within the Department of Environmental Health Sciences of the CWRU School of Medicine, The focus of the Center is on environmental health problems of the Cleveland community, especially as they relate to toxic exposures of children and their families. The Swetland Center has four major components relating to clinical care, research, public health, and medical education. The Center has an Environmental Health Clinic based at UHCMC and conducts clinical-based environmental research fostered by strong relationships with the local public health agencies, which address important local environmental problems including the built environment and indoor air quality. Medical education is a major component of the Swetland Center where it is developing environmental health as a theme throughout the education of medical students, residents, fellows, and community physicians. This environmental curriculum at CWRU includes yearly medical student community projects for the entire first year class on environmental health concerns. While the Center is relatively new, its Director, Dr. Dearborn, has had housing-related public health and research collaborations with both local health agencies for the past two decades.
Stanton L. Gerson, MD, Director
Jeremy Rich, MD, PhD, Co-Director
Mariesa Malinowski, Executive Director
The Center for Regenerative Medicine is a multi-institutional center composed of investigators from Case Western Reserve University, University Hospitals Case Medical Center, the Cleveland Clinic, Athersys, Inc., and The Ohio State University. Building on over 30 years of experience in adult stem cell research in northeast Ohio, the Center was created in 2003 with a $19.4 million award from the State of Ohio as a Wright Center of Innovation. An additional $8M award in 2006 from the State of Ohio's Biomedical Research and Commercialization Program (BRCP) was successfully completed and enabled 3 new clinical trials to enroll patients. In 2009, $5M was awarded by the Ohio Third Frontier (OTF) Research Commercialization Program (RCP) which further validated the Center's ability to achieve its mission to utilize human stem cell and tissue engineering technologies to treat human disease. In 2010, $1M was awarded to the NCRM by the OTF Biomedical Program (OTFBP) to advance the clinical treatment of spinal cord injury, and a $2.1M OTF Wright Program Project (WPP) award was made to create a consortium of quantitative analysis imaging systems for stem cells.
Dominique M. Durand, PhD, Director
Kenneth Gustafson, PhD, Associate Director
The Neural Engineering Center (NEC) is a coordinated group of scientists and engineers dedicated to research and education in an area at the interface between neuroscience and engineering. They share the common goal of analyzing the function of the nervous system, developing methods to restore damaged neurological function, and creating artificial neuronal systems by integrating physical, chemical, mathematical, biological and engineering tools.
The center was started in 2001 and replaced the Applied Neural Control Laboratory (ANCL) started in 1972. The center offers breadth and depth in Neural Engineering research and education in a highly ranked biomedical engineering department and medical school. The center is located on the campus of Case Western Reserve University and its members collaborate with four major hospitals in the Cleveland area.
The center provides core facilities in tissue culture, microscopy and histology. The center facilities also include an electrode fabrication laboratory, surgical suite for acute and sterile surgery, staffed by two full time animal technicians. The center also holds several laboratories in neural regeneration, neural interfacing, neural prosthetics, materials for neural interfacing computer modeling and in-vitro electrophysiology. The students, research associates and faculty can carry out research at many levels starting from cellular and molecular to animal experimentation and into the clinic. Many other facilities such as electronic design, microfabrication and rapid prototyping are also available in collaboration with other closely related centers, the Functional Stimulation Center (FES) and the Advanced Platform development Laboratory (APT). Center members work closely with the partner hospitals and the technology transfer office of CWRU for translation and clinical implementation of solutions restore neural function such as development of electrodes for communication with the nervous system, regenerating neural tissue, restoring function in paralysed patients, preventing seizures, motor disorders, incontinence aspiration or obstructive sleep apnea.
The center provides financial support for students through research and training grants. The graduates of this program have made significant contributions to the development and the growth of this fast growing area of neural engineering in academic, industrial and federal institutions.
Elaine A. Borawski, PhD, Director
The Prevention Research Center for Healthy Neighborhoods (PRCHN) at Case Western Reserve University was established in 2009 with funding from the Centers for Disease Control and Prevention (CDC). Built upon the foundation of two previous centers that merged to become the PRCHN - the Center for Health Promotion Research and the Center for Adolescent Health - the PRCHN seeks to foster partnerships within Cleveland’s neighborhoods for developing, testing, and implementing research strategies to prevent and reduce the burden of chronic disease. The PRCHN, midway into its second 5-year cycle of CDC funding, is a highly responsive and collaborative community-based research center that partners with public health agencies, community organizations, neighborhood leaders and residents to address significant environmental and lifestyle issues strongly linked to chronic disease and influenced by the conditions, disparities and resources of the neighborhood itself. Its faculty and staff have also served as an active partner and leader in the transformative process occurring in Cleveland around the concepts of health equity, collective action, and the understanding of multiple determinants of health.
The PRCHN supports a comprehensive research agenda that centers around food access and community nutrition, tobacco prevention and cessation, environments supporting healthy eating and active living, place-based health and health behavior surveillance, and community-clinical linkages and chronic disease management research. This includes core research project, Freshlink, that aims to increase nutritional food access (NFA) in low income neighborhoods throughout Cleveland. A goal of the PRCHN is to build capacity for community-based research among University and community partners by offering formal training programs (i.e., PEER Program, PRCHN Student Internship Program) monthly seminars, workshops and webinars, and by providing technical assistance, evaluation services and subject matter expertise to its community partners.
The PRCHN partners include experienced community based researchers, heads of local boards of health, more than 50 community and health organizations, neighborhood leaders and residents, and Affiliated Faculty from five schools within the University (College of Arts and Sciences, the Frances Payne Bolton School of Nursing, the Mandel School of Applied Social Sciences, and the School of Dental Medicine), to support the mission of the Center. Representatives from these local agencies and organizations serve on the PRCHN’s Network of Community Advisors (NOCA), offering guidance to identify emerging issues, set research and programmatic priorities, and ensure that the community’s voice informs our work.
Kevin D. Cooper, MD, Director
The Skin Cancer Research Institute engages the foremost experts in dermatology and oncology to work collaboratively across disciplines to identify new ways to treat and prevent skin cancers.The Skin Cancer Research Institute (SCRI) at Case Western Reserve University exists to discover causes of skin cancers, prevent skin cancers more effectively, and to develop new therapies for skin cancer treatment.
The Department of Dermatology is poised to create a research institute unique in scope on a national scale. Its efforts are validated by generous grant funding from the National Institutes of Health as well as through its continuous stream of groundbreaking discoveries over the past decade. What exists now within this rich infrastructure is an opportunity to transform discovery in skin cancer research. CWRU plans four new centers exclusively dedicated to the study of skin cancer, which will complement existing centers of excellence in the Department. The emerging centers will include a melanoma center, a basal/squamous cell carcinoma center, a photo medicine center, and an environmental agent center.
The Skin Cancer Research Institute has an opportunity to be unique in the nation in its capacity to bring new therapies "from lab to life" by aligning specialized skills and catalyzing new knowledge through these centers.
Insoo Hyun, PhD, Director
The CWRU Stem Cell Ethics Center serves as a focal point for campus-wide and international interdisciplinary scholarship and education. Housed in the Department of Bioethics, the Stem Cell Ethics Center provides an avenue to educate policy makers, regulators, and the general public about stem cell research of all forms and their translation to clinical practice. The Stem Cell Ethics Center bridges ethics and biotechnology by providing ethical and technical support, as well as a forum for directed application of stem cell ethics in the complex array of cultural, social, political, and economic issues.
Irina Pikuleva, PhD, Director
Nancy Vitale, Administrative Manager – 216.368.4752
The Visual Sciences Research Center (VSRC) was founded at Case Western Reserve University in 1996 and its mission is to promote the study of basic and clinical problems of the eye and visual system, expectantly leading to improvements in the prevention and treatment of major blinding disorders. The VSRC now comprises a multidisciplinary and comprehensive research program in vision and ophthalmology, with over 20 members in different departments including Ophthalmology and Visual Sciences, Pharmacology, Chemistry, Biomedical Engineering, Genetics, Medicine, Molecular Biology, Epidemiology & Biostatistics, Neurology, Neurosciences, Pathology, Pediatrics, and Physiology & Biophysics. VSRC scientists study basic and clinical aspects of the eye and focus on Retinal Degeneration, Aging and Diabetes, Biochemistry of Aging Lens, as well Glaucoma. Also, through multidisciplinary and comprehensive research involving both basic and clinical departments, the VSRC seeks to advance the visual sciences at the University and to promote its efforts to the scientific community.
The VSRC is supported by a National Eye Institute (NEI) funded P30 Core Grant (EY11373) and an NEI T32 Training Grant (EY007157), as well as generous contributions from both the university and University Hospitals.
The P30 grant supports five Core Modules, which enhance research quality in the most efficient and economical manner. The Core Modules are: Molecular Biology, Tissue Culture & Hybridoma, Microscopy & Digital Imaging, Histology, and Specialized Animal Resources with a Vision Function submodule. The provided services include genotyping, DNA cloning, paraffin or cryostat sections and slides, histological stains, high quality images, microscopy training, image analysis, maintenance and breeding of mice as well as in vivo eye imaging and testing. Each Core manager is very knowledgeable in his/her respective field with at least 15 years of experience. The P30 grant Core facilities provides first-rate service with quick turnaround times. Individual consultations are also available.
The T32 training grant offers the graduate course ‘Biochemical and molecular aspects of vision’ facilitated by Dr. Paul Park. This course, listed under the graduate program of three VSRC basic science departments - Pharmacology (PHRM 432), Neurosciences (NEUR 432) and Pathology (PATH 432), is taught by VSRC investigators, and covers the major components of the eye, visual processing and disease conditions. The course is open to all students, although VSTP Training Grant awardees take this course in their first or second year of training. Together with the Core Grant facilities, the T32 Training grant has had the most profound influence on the development and growth of the VSRC by bringing young investigators into the field that have full access to Core Grant facilities for pre- and post-doctoral training.
The VSRC coordinates an annual seminar series, which brings to campus renowned vision researchers on a regular basis during the academic year. An all-day annual symposium, which in recent years has been held on the Medical School Campus, comprises two external keynote speakers, talks from the faculty, post docs, ophthalmology residents and training grant awardees as well as poster presentations. In addition, monthly VSRC Primary Investigator meetings are a forum for the VSRC members to discuss science on a regular basis. Also, members from each Ophthalmology research lab take turns presenting their research at monthly Departmental Ophthalmology Research meetings. These three seminar series and the symposium foster a multitude of opportunities for collaboration, in addition to bringing non-vision investigators into the field.
Mitchell Drumm, PhD and Michael Konstan, MD, Co-Directors
Constance May, Administrative Assistant
The Cystic Fibrosis Research Center is a translational center composed of investigators from Case Western Reserve University and University Hospitals of Cleveland. The Center's research is funded by over $4 million in grants from the National Institutes of Health, the Cystic Fibrosis Foundation and other sources. The Center provides core facilities and services for investigators carrying out research related to cystic fibrosis, including a Clinical Studies core that provides clinical data for research studies and aids in IRB generation and study design, an Animal Models core that maintains the world's largest assortment of CF mouse models, a Bioanalyte core that measures a range of biomolecules (proteins, lipids, mRNA) from blood, tissues or cell culture, an Animal Imaging core that uses such technologies as MRI, PET and SECT to generate high resolution images of rodents, a Biostatistical core to carry out complex statistical analyses of CF related studies, a Histology core that generates slide-mounted and stained sections of tissues from animal or human samples and a Cell Culture core that provides facilities and media for cultured cells. These cores facilitate translational, or "bench to bedside" projects that take very mechanistic, basic research on CF-related biochemistry and cell biology to in vivo studies in animal models and on to humans. Center members have access to all the cores as well as involvement in the weekly seminar series focused on CF or pediatric pulmonary research.
Publications describing the School of Medicine are produced by the Office of Development, Alumni Relations, and Communications. Many articles and news reports are accessible via the Web under “news and highlights.” The medical school produces an annual report highlighting accomplishments in research, education and service.
For example, AlumniNews, produced by the Office of Alumni Relations, features updates to keep alumni connected to past colleagues, current students and happenings at the School of Medicine. This biannual newsletter publishes in the spring and fall, and all alumni who spent the majority of their time within the School of Medicine (MD and PhD alumni) should receive a printed issue in the mail. Copies are also delivered to locations around the medical school to reach MD and PhD students, and a link to a PDF version is emailed to all students. This university wide-publication is distributed electronically to all CWRU alumni once a month. Each school within the university submits one news bullet for publication and can be viewed online. The Reunion Newsletter is distributed to all alumni who are celebrating milestone reunion years from the School of Medicine. This newsletter is published three times during the year for celebratory years. The third issue each year serves as a follow-up on the celebration. This last publication is also sent to the next year's reunion classes to create momentum and get alumni involved in upcoming reunions.
Established in 1974 by friends of the late professor of anesthesiology (from 1969 until his death in 1974), this annual lecture is presented by teachers of the science of anesthesia.
This lecture, about cardiovascular surgery, was established in 1989. At what is now known as the Case Western Reserve University School of Medicine, Claude S. Beck, MD, was demonstrator of surgery in 1924 to 1925; professor of neurosurgery in 1940; and the first professor of cardiovascular surgery in the United States from 1952 until 1965.
Established in 2001 with contributions from friends of colleagues of this former School of Medicine dean (1980 to 1989), this annual lecture is delivered by distinguished scholars in child development.
Established in 1999 by family, friends and colleagues of this alumnus and associate clinical professor, guest lecturers discuss the basic science behind disease and its application to patient care through this program.
Established in 1955 in memory of the Cleveland attorney Theodore R. Bloomfield by his widow and his son, this lecture brings outstanding members of the medical profession from around this country and abroad to discuss new concepts and developments in medicine with the medical community and allied professions.
This lecture was established in 2002 in memory of the father of Clark E. Bruner and grandfather of William E. Bruner II, MD, a 1975 medical school alumnus, with gifts coming from them as well as Susan F. Bruner.
This annual lecture is presented by an outstanding individual who has achieved or helped achieve a significant advance in medicine or a closely related field and whose presentation would be of great interest to members of the medical profession. It is supported by a fund established in 1993. Courtney Burton Jr., was chair of the board of Oglebay Norton Co. from 1957 until shortly before his death in 1992.
This lecture series in gastroenterology has been supported by a fund established in 1965 by Lottie Cahen, widow of the founder and former president of World Publishing Co., in memory of her late husband.
Lecturers in medicine and engineering deliver this lectureship at the discretion of the University president thanks to a fund begun in 1993 by Paul R. Frohring.
Through an endowment, Rosalee Greenfield Weiss, PhD, and Raymond A. Weiss, PhD, established this annual lecture in 1997 to honor her father, Nathan S. Greenfield, a pharmacist who owned Wade Park Pharmacy in Cleveland from 1914 to 1956; her mother, Corinne Sternheimer Greenfield; and Lynn Stuart Weiss, daughter of the benefactors, who died of cancer in her mid-20s in 1971.
This annual lecture or series of lectures is presented by one or more distinguished visiting researchers selected by the dean of the School of Medicine or his or her designee. It/they are made possible because of support received in 1998 by the estate of Zella Hall.
Founded in 1913 by G. W. Crile, 1864-1943, in honor of H. Melville Hanna, philanthropist and founder of the MA Hanna Co., the Hanna Lectures are delivered by distinguished basic scientists from this country and abroad.
Established in 1985 by the members of the Department of Surgery of MetroHealth Medical Center in honor of their former chair and Payne Professor of Surgery, this series of lectures in surgery is delivered by distinguished leaders in American surgery.
This lecture, for residents and visiting staff members in ophthalmology, was established in 1967 by the Wright Foundation.
This lecture is presented by a distinguished visiting lecturer with the goal of advancing the study of bioethics. It was established in 1994.
In this annual lecture, established in 1996, a distinguished visiting lecturer promotes quality health care by emphasizing new developments in the identification and treatment of life-threatening cardiac arrhythmia. Rita Ann Kicher was the daughter of Thomas Kicher, PhD, a triple alumnus, long-time faculty member, and dean (1992-1997) of the Case School of Engineering. At the time of her death, she was a systems analyst at University Hospitals of Cleveland’s Center for Quality Assessment and Utilization Management.
These lecturers are distinguished visitors whose presentations advance the study of plastic and reconstructive surgery. The lectureship was established in 1994. Dr. Kiehn is the former head of plastic and reconstructive surgery, and Dr. Desprez followed him in that role.
This lectureship is named for an internationally respected lung specialist and professor emeritus of pathology at the School of Medicine. Established in 2000 by the late Dr. Kleinerman’s daughters, friends and colleagues, the lectureship each year supports a distinguished visiting lecturer whose presentation advances the study of pulmonary pathobiology. The lecturer is selected by a faculty committee that includes members having appointments at MetroHealth Medical Center. The members of the committee are chosen by the dean of the School of Medicine.
The lecture honors an alumnus of the Class of 1957 and was established in his memory in 1989 by family, friends and colleagues to advance the study of pathology.
The fund was established in 1982 by family, friends and colleagues of former faculty member Lester Krampitz, MD, to honor him with a lecture fund in microbiology. It is intended to facilitate the interchange of ideas, a process Dr. Krampitz, who joined the faculty in 1946 and retired in 1978, believes is vital to scientific research.
Established in 1955 by friends of this alumnus of the Class of 1904, in his memory, this lecture presents outstanding speakers on clinical developments in surgery.
This fund was established in 1991 by friends and colleagues of the late forensic pathologist, medical school faculty members, and university provost.
Established in 1999 by family and friends of the late endocrinologist, oncologist and faculty member, this lecture features a cancer-related topic at the School of Medicine.
Established in 1995 by Dr. Post’s friends and colleagues in the Community Dialysis Center, in memory of the former faculty member and head of nephrology, this lecture features a distinguished visiting expert in the field of nephrology.
Established in 1991 and named for the late physician, surgeon, researcher, and medical school head of ophthalmology, this lecture features a visiting expert in the Department of Ophthalmology.
Established in 1995 by the Department of Medicine in honor of Frederick C. Robbins, MD, dean emeritus of the School of Medicine, university professor emeritus, and Nobel Prize winner, this lecture features a distinguished visiting expert each year in the Department of Medicine.
Established in 1997 by Mrs. Florence M. Sable in honor of her late husband, who was professor emeritus of biochemistry, this lecture advances the study of biochemistry via a visiting expert selected by the chairperson of the Department of Biochemistry.
Established by colleagues, students, family and friends in memory of the former head of the Department of Medicine of MetroHealth Medical Center, this lecture involves an annual two-day visit of a leading cardiologist, who presents the lecture and grand rounds to house officers and students of the School of Medicine.
Originally established in 1990 by friends and family and named the Robert Sternlicht Memorial Fund, these lectures feature distinguished experts whose presentations will advance the study of oncology at the School of Medicine. Lecturers are chosen by the chair of the Department of Pharmacology and the director of the comprehensive cancer center. Robert Sternlicht was the son of Himan Sternlicht, PhD, associate professor emeritus of pharmacology.
Established in 1981 in memory of the former professor of biochemistry and chair of the Department of Biochemistry, this lecture is delivered by a scientist of the highest caliber in a field related to those in which Dr. Utter was interested. Lecturers are chosen by the chair of the Department of Biochemistry.
Established in 1972 in the Department of Medicine, this lecture honors the memory of the man who, at the time of his death in 1970, was the John Huntington Hord Professor and chair of the Department of Medicine of the School of Medicine and University Hospitals.
Established in 1994 in memory of the late chair and professor of biochemistry and former provost of the university, this fund supports an annual Page-Wood symposium, co-sponsored by the School of Medicine and the Cleveland Clinic Foundation, featuring a leader in the field of biochemistry, an annual guest lecturer in biochemistry, and an annual guest lecturer selected by faculty with the rank of assistant professor in the Department of Biochemistry.