Systems Biology, BS
Degree: Bachelor of Science (BS)
Major: Systems Biology
Program Overview
Systems biology is a rapidly emerging area of research activity at the interface of mathematics, computer science, and the biological sciences. Many modern areas of biology research (e.g., biochemical, neural, behavioral, and ecosystem networks) require the mastery of advanced quantitative and computational skills. The Systems Biology, BS degree program is intended to provide the quantitative and multidisciplinary understanding that is necessary for work in these areas. This skill set is different from that produced by traditional undergraduate programs in biology. Consequently, the Systems Biology, BS program adds two core courses (in modeling and analysis of biological systems) beyond the three core lecture courses in the Biology, BA and Biology, BS programs, as well as foundation courses from computer science and advanced mathematics. The traditional biology core laboratory courses are not required, but may be taken as electives. Undergraduate research is strongly recommended (as BIOL 388S and BIOL 390) but is not formally required.
The Systems Biology, BS program provides options for specialization in a variety of areas, including biotechnology and genetic engineering, molecular and cellular biology, genetics, immunology, chemical biology, physiology and biophysics, neurobiology and animal behavior, developmental biology, population biology, ecology, and environmental science. Theoretical, mathematical, and computational approaches to these fields are emphasized in the Systems Biology, BS program.
Ordinarily, all students begin their biology programs in their first year.
Learning Outcomes
- Students will be able to demonstrate knowledge of biological concepts.
- Students will be able to use mathematical and computational tools to answer biological questions.
- Students will be able to demonstrate clarity of thought and logical rigor in analyzing problems. They will be able to formulate and refine clear questions and design effective tests of hypotheses.
- Students will be able to communicate effectively orally and in writing.
- Students will be able to translate biological phenomena intomathematical/computational language and vice versa.
Advising
Biology faculty advisors are assigned to students at the time of major or minor declaration. All biology majors are required to meet with their departmental advisors at least once each semester to discuss their academic program, receive clearance for electronic course registration, and obtain approval for any drops, adds, or withdrawals. Please contact the undergraduate services coordinator for the Department of Biology for information about major or minor declaration.
Undergraduate Policies
For undergraduate policies and procedures, please review the Undergraduate Academics section of the General Bulletin.
Combined Bachelor's/Master's Programs
Undergraduate students may participate in accelerated programs toward graduate or professional degrees. For more information and details of the policies and procedures related to accelerated studies, please visit the Undergraduate Academics section of the General Bulletin.
Program Requirements
Students seeking to complete this major and degree program must meet the general requirements for bachelor's degrees and the Unified General Education Requirements. Students completing this program as a secondary major while completing another undergraduate degree program do not need to satisfy the school-specific requirements associated with this major.
| Code | Title | Credit Hours |
|---|---|---|
| Core Courses | ||
| BIOL 214 | Genes, Evolution and Ecology | 3 |
| BIOL 215 | Cells and Proteins | 3 |
| BIOL 216 | Development and Physiology | 3 |
| BIOL 300 | Dynamics of Biological Systems: A Quantitative Introduction to Biology | 3 |
| BIOL 306 | Mathematical Analysis of Biological Models | 3 |
| Choose 6 credits from one subspecialty: | 6-8 | |
| Neuroscience subspecialty courses: | ||
| Sensory Biology | ||
| Seminar on Unifying Concepts in Neuroscience a | ||
| Introduction to Neurobiology | ||
| Neurobiology of Behavior | ||
| Brain Evolution and Function | ||
| Computational Neuroscience b | ||
| Principles of Neural Science | ||
| Bioinformatics and Genetics subspecialty courses: | ||
| Biotechnology Laboratory: Genes and Genetic Engineering | ||
| Genetics | ||
| Functional Genomics | ||
| Plant Genomics and Proteomics | ||
| Introduction to Bioinformatics | ||
| Technologies in Bioinformatics | ||
| Bioinformatics for Systems Biology | ||
| Ecology and Evolutionary Biology subspecialty courses: | ||
| Herpetology | ||
| Ecology and Evolution of City Life a | ||
| Introductory Entomology | ||
| Aquatic Biology | ||
| Ichthyology | ||
| Mammal Diversity and Evolution | ||
| Principles of Evolution | ||
| Principles of Ecology | ||
| Ecology and Evolution of Infectious Diseases b | ||
| Ecophysiology of Global Change | ||
| Animal Behavior | ||
| Research Methods in Evolutionary Biology | ||
| Topics in Evolutionary Biology | ||
| Foundations of Advanced Ecology | ||
| Foundations of Advanced Evolution | ||
| Cellular and Molecular Biology subspecialty courses: | ||
| Fundamental Immunology | ||
| Introduction to Stem Cell Biology | ||
| Cell Biology | ||
| The Human Microbiome | ||
| Parasitology | ||
| Microbiology | ||
| Laboratory for Microbiology | ||
| Principles of Developmental Biology | ||
| BIOL Electives c,d | 9 | |
| Mathematics and Statistics Core Courses: | ||
| MATH 121 | Calculus for Science and Engineering I | 4 |
| MATH 122 | Calculus for Science and Engineering II | 4 |
| or MATH 124 | Calculus II | |
| MATH 223 | Calculus for Science and Engineering III | 3 |
| or MATH 227 | Calculus III | |
| MATH 224 | Elementary Differential Equations | 3 |
| or MATH 228 | Differential Equations | |
| STAT 312 | Basic Statistics for Engineering and Science | 3 |
| Chemistry Core Courses: | ||
| CHEM 105 | Principles of Chemistry I | 3 |
| CHEM 106 | Principles of Chemistry II | 3 |
| CHEM 113 | Principles of Chemistry Laboratory | 2 |
| Physics Core Courses: | ||
| PHYS 121 | General Physics I - Mechanics | 4 |
| or PHYS 123 | Physics and Frontiers I - Mechanics | |
| PHYS 122 | General Physics II - Electricity and Magnetism | 4 |
| or PHYS 124 | Physics and Frontiers II - Electricity and Magnetism | |
| Computer Science Core Courses: | ||
| ECSE/CSDS 132 | Programming in Java | 3 |
| ECSE/CSDS 233 | Introduction to Data Structures | 4 |
| Systems Electives | 6-7 | |
| Choose at least 6 credits of the following: | ||
| Fitting Models to Data: Maximum Likelihood Methods and Model Selection | ||
| Applied Probability and Stochastic Processes for Biology | ||
or MATH 319 | Applied Probability and Stochastic Processes for Biology | |
| Design and Analysis of Biological Experiments | ||
| Ecology and Evolution of Infectious Diseases b | ||
| Computational Neuroscience b | ||
or MATH 378 | Computational Neuroscience | |
| Algorithms a | ||
| Introduction to Artificial Intelligence | ||
| Introduction to Database Systems | ||
| Introduction to Information Theory | ||
| Biomedical Signals and Systems | ||
| Modeling of Biomedical Systems | ||
| Signals and Systems | ||
| Signal Processing | ||
| Modeling and Simulation of Continuous Dynamical Systems | ||
| Engineering Optimization | ||
| Introduction to Linear Algebra for Applications | ||
| Discrete Mathematics | ||
or CSDS 302 | Discrete Mathematics | |
or ECSE 302 | Discrete Mathematics | |
| Introduction to Scientific Computing | ||
| Mathematics and Brain a | ||
| Mathematical Modeling | ||
| Introduction to Probability | ||
| Introduction to Information Theory | ||
| Data Analysis and Linear Regression Models | ||
| Multivariate Analysis and Data Mining | ||
| Statistics for Signal Processing | ||
| Introduction to Stochastic Processes | ||
| Survey of Bioinformatics: Programming for Bioinformatics | ||
| Total Credit Hours | 76-79 | |
- a
Fulfills UGER Disciplinary Communication course requirement.
- b
These courses can fulfill the Systems Elective requirement or the Subspecialty Courses requirement, but not both.
- c
Excluding 100-level courses.
- d
Undergraduate research (BIOL 388S & BIOL 390) strongly recommended.
Concentrations in Areas of the Biological Sciences
Students are encouraged to utilize their elective courses in the biology major to take advantage of concentrations in various specialized areas. These concentrations have been developed between the biology department, the basic science departments of the School of Medicine, and other departments. Currently, concentrations have been developed in the following areas: biotechnology and genetic engineering; computational biology; developmental biology; genetics; cell and molecular biology; neurobiology and animal behavior; population biology, ecology and environmental science. Note: these concentrations are informal; they are not declared, and will not appear on the student’s diploma or transcript.
Departmental Honors
To receive a bachelor’s degree “with Honors in Biology” (formally noted on the transcript), the student must meet the following criteria:
- Maintain a 3.6 overall grade point average, with a 3.8 in BIOL courses. GPA requirements refer only to courses taken since the start of their third semester at CWRU. Alternatively, students may be nominated for Honors by their research advisor.
- Sign an attestation of their record of academic integrity.
- Carry out 6 credit hours of independent research (taken as BIOL courses) or the equivalent at Case Western Reserve University.
- Write a senior honors thesis with the approval of the Research Sponsor and (if applicable) the Biology Sponsor.
- Submit no later than one week prior to the scheduled thesis defense the thesis for review by an ad hoc honors committee.
- Successfully defend the thesis at an oral examination.
Additional information and application forms are available from the biology department office and website.
Sample Plan of Study
| First Year | ||
|---|---|---|
| Fall | Credit Hours | |
| BIOL 214 | Genes, Evolution and Ecology | 3 |
| CHEM 105 | Principles of Chemistry I | 3 |
| CHEM 113 | Principles of Chemistry Laboratory | 2 |
| MATH 121 | Calculus for Science and Engineering I | 4 |
| Academic Inquiry Seminar, Breadth, or Elective course a | 3 | |
| Credit Hours | 15 | |
| Spring | ||
| BIOL 215 | Cells and Proteins | 3 |
| CHEM 106 | Principles of Chemistry II | 3 |
| MATH 122 or MATH 124 | Calculus for Science and Engineering II or Calculus II | 4 |
| Academic Inquiry Seminar, Breadth, or Elective course a | 3 | |
| Open Elective | 3 | |
| Credit Hours | 16 | |
| Second Year | ||
| Fall | ||
| BIOL 216 | Development and Physiology | 3 |
| MATH 223 or MATH 227 | Calculus for Science and Engineering III or Calculus III | 3 |
| PHYS 121 or ECSE 132 | General Physics I - Mechanics b or Programming in Java | 3-4 |
| Breadth, or Elective course a | 3 | |
| Elective | 3 | |
| Credit Hours | 16 | |
| Spring | ||
| MATH 224 or MATH 228 | Elementary Differential Equations or Differential Equations | 3 |
| PHYS 122 or PHYS 121 | General Physics II - Electricity and Magnetism b or General Physics I - Mechanics | 4 |
| STAT 312 | Basic Statistics for Engineering and Science | 3 |
| Breadth, or Elective course a | 3 | |
| Open Elective | 3 | |
| Credit Hours | 16 | |
| Third Year | ||
| Fall | ||
| ECSE 132 | Programming in Java | 3 |
| MATH 304 or CSDS 302 | Discrete Mathematics or Discrete Mathematics | 3 |
| Breadth, or Elective course a | 3 | |
| BIOL Electives | 6 | |
| Credit Hours | 15 | |
| Spring | ||
| BIOL 300 | Dynamics of Biological Systems: A Quantitative Introduction to Biology | 3 |
| BIOL 306 | Mathematical Analysis of Biological Models | 3 |
| ECSE 233 | Introduction to Data Structures | 4 |
| Breadth, or Elective course a | 3 | |
| Elective | 3 | |
| Credit Hours | 16 | |
| Fourth Year | ||
| Fall | ||
| BIOL 388S | Undergraduate Research - SAGES Capstone c | 3 |
| Breadth, or Elective course a | 3 | |
| Elective | 3 | |
| Subspecialty Elective | 3 | |
| Systems Elective | 3 | |
| Credit Hours | 15 | |
| Spring | ||
| BIOL 390 | Advanced Undergraduate Research c | 3 |
| Breadth, or Elective course a | 3 | |
| Subspecialty Elective | 3 | |
| Systems Elective | 3 | |
| BIOL Elective (if needed) or Open Elective | 3 | |
| Credit Hours | 15 | |
| Total Credit Hours | 124 | |