Systems Biology, BS

Degree: Bachelor of Science (BS)
Major: Systems Biology


Program Overview

Systems biology is a rapidly emerging area of research activity at the interface of mathematics, computer science, and the biological sciences. Many modern areas of biology research (e.g., biochemical, neural, behavioral, and ecosystem networks) require the mastery of advanced quantitative and computational skills. The Systems Biology, BS degree program is intended to provide the quantitative and multidisciplinary understanding that is necessary for work in these areas. This skill set is different from that produced by traditional undergraduate programs in biology. Consequently, the Systems Biology, BS program adds two core courses (in modeling and analysis of biological systems) beyond the three core lecture courses in the Biology, BA and Biology, BS programs, as well as foundation courses from computer science and advanced mathematics. The traditional biology core laboratory courses are not required, but may be taken as electives. Undergraduate research is strongly recommended (as BIOL 388S and BIOL 390) but is not formally required.

The Systems Biology, BS program provides options for specialization in a variety of areas, including biotechnology and genetic engineering, molecular and cellular biology, genetics, immunology, chemical biology, physiology and biophysics, neurobiology and animal behavior, developmental biology, population biology, ecology, and environmental science. Theoretical, mathematical, and computational approaches to these fields are emphasized in the Systems Biology, BS program. 

Ordinarily, all students begin their biology programs in their first year.

Learning Outcomes

  • Students will be able to demonstrate knowledge of biological concepts.
  • Students will be able to use mathematical and computational tools to answer biological questions.
  • Students will be able to demonstrate clarity of thought and logical rigor in analyzing problems. They will be able to formulate and refine clear questions and design effective tests of hypotheses.
  • Students will be able to communicate effectively orally and in writing.
  • Students will be able to translate biological phenomena intomathematical/computational language and vice versa.

Advising

Biology faculty advisors are assigned to students at the time of major or minor declaration. All biology majors are required to meet with their departmental advisors at least once each semester to discuss their academic program, receive clearance for electronic course registration, and obtain approval for any drops, adds, or withdrawals. Please contact the undergraduate services coordinator for the Department of Biology for information about major or minor declaration.

Undergraduate Policies

For undergraduate policies and procedures, please review the Undergraduate Academics section of the General Bulletin.

Combined Bachelor's/Master's Programs

Undergraduate students may participate in accelerated programs toward graduate or professional degrees. For more information and details of the policies and procedures related to accelerated studies, please visit the Undergraduate Academics section of the General Bulletin.

Program Requirements

Students seeking to complete this major and degree program must meet the general requirements for bachelor's degrees and the Unified General Education Requirements. Students completing this program as a secondary major while completing another undergraduate degree program do not need to satisfy the school-specific requirements associated with this major.

Core Courses
BIOL 214Genes, Evolution and Ecology3
BIOL 215Cells and Proteins3
BIOL 216Development and Physiology3
BIOL 300Dynamics of Biological Systems: A Quantitative Introduction to Biology3
BIOL 306Mathematical Analysis of Biological Models3
Choose 6 credits from one subspecialty:6-8
Neuroscience subspecialty courses:
Sensory Biology
Seminar on Unifying Concepts in Neuroscience a
Introduction to Neurobiology
Neurobiology of Behavior
Brain Evolution and Function
Computational Neuroscience b
Principles of Neural Science
Bioinformatics and Genetics subspecialty courses:
Biotechnology Laboratory: Genes and Genetic Engineering
Genetics
Functional Genomics
Plant Genomics and Proteomics
Introduction to Bioinformatics
Technologies in Bioinformatics
Bioinformatics for Systems Biology
Ecology and Evolutionary Biology subspecialty courses:
Herpetology
Ecology and Evolution of City Life a
Introductory Entomology
Aquatic Biology
Ichthyology
Mammal Diversity and Evolution
Principles of Evolution
Principles of Ecology
Ecology and Evolution of Infectious Diseases b
Ecophysiology of Global Change
Animal Behavior
Research Methods in Evolutionary Biology
Topics in Evolutionary Biology
Foundations of Advanced Ecology
Foundations of Advanced Evolution
Cellular and Molecular Biology subspecialty courses:
Fundamental Immunology
Introduction to Stem Cell Biology
Cell Biology
The Human Microbiome
Parasitology
Microbiology
Laboratory for Microbiology
Principles of Developmental Biology
BIOL Electives c,d9
Mathematics and Statistics Core Courses:
MATH 121Calculus for Science and Engineering I4
MATH 122Calculus for Science and Engineering II4
or MATH 124 Calculus II
MATH 223Calculus for Science and Engineering III3
or MATH 227 Calculus III
MATH 224Elementary Differential Equations3
or MATH 228 Differential Equations
STAT 312Basic Statistics for Engineering and Science3
Chemistry Core Courses:
CHEM 105Principles of Chemistry I3
CHEM 106Principles of Chemistry II3
CHEM 113Principles of Chemistry Laboratory2
Physics Core Courses:
PHYS 121General Physics I - Mechanics4
or PHYS 123 Physics and Frontiers I - Mechanics
PHYS 122General Physics II - Electricity and Magnetism4
or PHYS 124 Physics and Frontiers II - Electricity and Magnetism
Computer Science Core Courses:
ECSE/CSDS 132Programming in Java3
ECSE/CSDS 233Introduction to Data Structures4
Systems Electives6-7
Choose at least 6 credits of the following:
Fitting Models to Data: Maximum Likelihood Methods and Model Selection
Applied Probability and Stochastic Processes for Biology
Applied Probability and Stochastic Processes for Biology
Design and Analysis of Biological Experiments
Ecology and Evolution of Infectious Diseases b
Computational Neuroscience b
Computational Neuroscience
Algorithms a
Introduction to Artificial Intelligence
Introduction to Database Systems
Introduction to Information Theory
Biomedical Signals and Systems
Modeling of Biomedical Systems
Signals and Systems
Signal Processing
Modeling and Simulation of Continuous Dynamical Systems
Engineering Optimization
Introduction to Linear Algebra for Applications
Discrete Mathematics
Discrete Mathematics
Discrete Mathematics
Introduction to Scientific Computing
Mathematics and Brain a
Mathematical Modeling
Introduction to Probability
Introduction to Information Theory
Data Analysis and Linear Regression Models
Multivariate Analysis and Data Mining
Statistics for Signal Processing
Introduction to Stochastic Processes
Survey of Bioinformatics: Programming for Bioinformatics
Total Credit Hours76-79
a

Fulfills UGER Disciplinary Communication course requirement.

b

These courses can fulfill the Systems Elective requirement or the Subspecialty Courses requirement, but not both.

c

Excluding 100-level courses.

d

Undergraduate research (BIOL 388S & BIOL 390) strongly recommended.

Concentrations in Areas of the Biological Sciences

Students are encouraged to utilize their elective courses in the biology major to take advantage of concentrations in various specialized areas. These concentrations have been developed between the biology department, the basic science departments of the School of Medicine, and other departments. Currently, concentrations have been developed in the following areas: biotechnology and genetic engineering; computational biology; developmental biology; genetics; cell and molecular biology; neurobiology and animal behavior; population biology, ecology and environmental science. Note: these concentrations are informal; they are not declared, and will not appear on the student’s diploma or transcript.

Departmental Honors

To receive a bachelor’s degree “with Honors in Biology” (formally noted on the transcript), the student must meet the following criteria:

  1. Maintain a 3.6 overall grade point average, with a 3.8 in BIOL courses. GPA requirements refer only to courses taken since the start of their third semester at CWRU. Alternatively, students may be nominated for Honors by their research advisor.
  2. Sign an attestation of their record of academic integrity.
  3. Carry out 6 credit hours of independent research (taken as BIOL courses) or the equivalent at Case Western Reserve University.
  4. Write a senior honors thesis with the approval of the Research Sponsor and (if applicable) the Biology Sponsor.
  5. Submit no later than one week prior to the scheduled thesis defense the thesis for review by an ad hoc honors committee.
  6. Successfully defend the thesis at an oral examination.

Additional information and application forms are available from the biology department office and website.

Sample Plan of Study

Plan of Study Grid
First Year
FallCredit Hours
BIOL 214 Genes, Evolution and Ecology 3
CHEM 105 Principles of Chemistry I 3
CHEM 113 Principles of Chemistry Laboratory 2
MATH 121 Calculus for Science and Engineering I 4
Academic Inquiry Seminar, Breadth, or Elective course a 3
 Credit Hours15
Spring
BIOL 215 Cells and Proteins 3
CHEM 106 Principles of Chemistry II 3
MATH 122
Calculus for Science and Engineering II
or Calculus II
4
Academic Inquiry Seminar, Breadth, or Elective course a 3
Open Elective 3
 Credit Hours16
Second Year
Fall
BIOL 216 Development and Physiology 3
MATH 223
Calculus for Science and Engineering III
or Calculus III
3
PHYS 121
General Physics I - Mechanics b
or Programming in Java
3-4
Breadth, or Elective course a 3
Elective 3
 Credit Hours16
Spring
MATH 224
Elementary Differential Equations
or Differential Equations
3
PHYS 122
General Physics II - Electricity and Magnetism b
or General Physics I - Mechanics
4
STAT 312 Basic Statistics for Engineering and Science 3
Breadth, or Elective course a 3
Open Elective 3
 Credit Hours16
Third Year
Fall
ECSE 132 Programming in Java 3
MATH 304
Discrete Mathematics
or Discrete Mathematics
3
Breadth, or Elective course a 3
BIOL Electives 6
 Credit Hours15
Spring
BIOL 300 Dynamics of Biological Systems: A Quantitative Introduction to Biology 3
BIOL 306 Mathematical Analysis of Biological Models 3
ECSE 233 Introduction to Data Structures 4
Breadth, or Elective course a 3
Elective 3
 Credit Hours16
Fourth Year
Fall
BIOL 388S Undergraduate Research - SAGES Capstone c 3
Breadth, or Elective course a 3
Elective 3
Subspecialty Elective 3
Systems Elective 3
 Credit Hours15
Spring
BIOL 390 Advanced Undergraduate Research c 3
Breadth, or Elective course a 3
Subspecialty Elective 3
Systems Elective 3
BIOL Elective (if needed) or Open Elective 3
 Credit Hours15
 Total Credit Hours124
a

Unified General Education Requirement.

b

Computer science-oriented students are recommended to take ECSE 132 before the PHYS 121 / PHYS 122 sequence. Other students may take physics first. 

c

Undergraduate research (BIOL 388S and BIOL 390) are not required, but strongly recommended.